Application | Comment | Organism |
---|---|---|
medicine | enzyme is an important target in therapy of cancer | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diprotinin A | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
eotaxin + H2O | Homo sapiens | i.e. CCL11, chemokine | ? | - |
? | |
gastrin releasing peptide + H2O | Homo sapiens | sequential cleavage of 2 N-terminal peptides | ? | - |
? | |
glucagon-like peptide 1 + H2O | Homo sapiens | i.e. GLP 1 | ? | - |
? | |
glucagon-like peptide 2 + H2O | Homo sapiens | i.e. GLP 2 | ? | - |
? | |
IFN-gamma-inducible protein 10 + H2O | Homo sapiens | i.e. IP-10 or CXCL10, chemokine | ? | - |
? | |
IFN-inducible T-cell alpha-chemoattractant + H2O | Homo sapiens | i.e. I-TAC or CXCL11, chemokine | ? | - |
? | |
macrophage-derived chemokine + H2O | Homo sapiens | i.e. MDC or CCL22 | ? | - |
? | |
monokine induced by IFN-gamma + H2O | Homo sapiens | i.e. MIg or CXCL9, chemokine | ? | - |
? | |
additional information | Homo sapiens | physiological function of enzyme activities with natural substrates, enzyme is involved in immune regulation, altered enzyme activity and expression level, and diverse physiological effects of increased enzyme expression, in cancer cells, overview, disregulation of the enzyme may contribute to cancer development | ? | - |
? | |
NPY + H2O | Homo sapiens | important step in the neuropeptide-Y NPY-mediated angiogenesis | ? | - |
? | |
RANTES + H2O | Homo sapiens | i.e. CCL5 or regulated on activation normal T-cell expressed and secreted, chemokine | ? | - |
? | |
stromal cell derived factor 1 + H2O | Homo sapiens | i.e. SDF-1 or CXCL12, chemokine | ? | - |
? | |
substance P + H2O | Homo sapiens | i.e. SP, sequential cleavage of full length substance P | peptides SP(3-11) + SP(5-11) + ? | both fragments are still active | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
basal cell carcinoma cell | - |
Homo sapiens | - |
hairy cell leukemia cell | - |
Homo sapiens | - |
hepatocarcinoma cell | CD26 | Homo sapiens | - |
lung adenocarcinoma cell | - |
Homo sapiens | - |
lymphocyte | increased enzyme activity in chronic lymphocytic leukemia | Homo sapiens | - |
melanocyte | - |
Homo sapiens | - |
additional information | changes in enzyme expression are observed in numerous types of human malignancies as well as in blood plasma of cancer patients | Homo sapiens | - |
ovarian carcinoma cell | overexpression | Homo sapiens | - |
plasma | - |
Homo sapiens | - |
prostate tumor cell | - |
Homo sapiens | - |
T-cell | - |
Homo sapiens | - |
T-cell leukemia cell | - |
Homo sapiens | - |
T-cell lymphoma cell | - |
Homo sapiens | - |
thyroid carcinoma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
eotaxin + H2O | i.e. CCL11, chemokine | Homo sapiens | ? | - |
? | |
gastrin releasing peptide + H2O | sequential cleavage of 2 N-terminal peptides | Homo sapiens | ? | - |
? | |
glucagon-like peptide 1 + H2O | i.e. GLP 1 | Homo sapiens | ? | - |
? | |
glucagon-like peptide 2 + H2O | i.e. GLP 2 | Homo sapiens | ? | - |
? | |
IFN-gamma-inducible protein 10 + H2O | i.e. IP-10 or CXCL10, chemokine | Homo sapiens | ? | - |
? | |
IFN-inducible T-cell alpha-chemoattractant + H2O | i.e. I-TAC or CXCL11, chemokine | Homo sapiens | ? | - |
? | |
macrophage-derived chemokine + H2O | i.e. MDC or CCL22 | Homo sapiens | ? | - |
? | |
monokine induced by IFN-gamma + H2O | i.e. MIg or CXCL9, chemokine | Homo sapiens | ? | - |
? | |
additional information | enzyme binds to adenosine deaminase ADA | Homo sapiens | ? | - |
? | |
additional information | physiological function of enzyme activities with natural substrates, enzyme is involved in immune regulation, altered enzyme activity and expression level, and diverse physiological effects of increased enzyme expression, in cancer cells, overview, disregulation of the enzyme may contribute to cancer development | Homo sapiens | ? | - |
? | |
NPY + H2O | important step in the neuropeptide-Y NPY-mediated angiogenesis | Homo sapiens | ? | - |
? | |
NPY(1-36) peptide + H2O | peptide derived from the neuropeptide-Y | Homo sapiens | ? | - |
? | |
NPY(3-36) peptide + H2O | peptide derived from the neuropeptide-Y | Homo sapiens | ? | - |
? | |
RANTES + H2O | i.e. CCL5 or regulated on activation normal T-cell expressed and secreted, chemokine | Homo sapiens | ? | - |
? | |
stromal cell derived factor 1 + H2O | i.e. SDF-1 or CXCL12, chemokine | Homo sapiens | ? | - |
? | |
substance P + H2O | i.e. SP, sequential cleavage of full length substance P | Homo sapiens | peptides SP(3-11) + SP(5-11) + ? | both fragments are still active | ? |
Synonyms | Comment | Organism |
---|---|---|
CD26 | - |
Homo sapiens |
dipeptidyl peptidase IV | - |
Homo sapiens |
DPP-IV | - |
Homo sapiens |
More | enzyme belongs to the group of dipeptidylpeptidase-IV activity and/or structure homologues, i.e. DASH | Homo sapiens |