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Literature summary for 3.4.14.5 extracted from

  • Busek, P.; Malik, R.; Sedo, A.
    Dipeptidyl peptidase IV activity and/or structure homologues (DASH) and their substrates in cancer (2004), Int. J. Biochem. Cell Biol., 36, 408-421.
    View publication on PubMed

Application

Application Comment Organism
medicine enzyme is an important target in therapy of cancer Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
diprotinin A
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
eotaxin + H2O Homo sapiens i.e. CCL11, chemokine ?
-
?
gastrin releasing peptide + H2O Homo sapiens sequential cleavage of 2 N-terminal peptides ?
-
?
glucagon-like peptide 1 + H2O Homo sapiens i.e. GLP 1 ?
-
?
glucagon-like peptide 2 + H2O Homo sapiens i.e. GLP 2 ?
-
?
IFN-gamma-inducible protein 10 + H2O Homo sapiens i.e. IP-10 or CXCL10, chemokine ?
-
?
IFN-inducible T-cell alpha-chemoattractant + H2O Homo sapiens i.e. I-TAC or CXCL11, chemokine ?
-
?
macrophage-derived chemokine + H2O Homo sapiens i.e. MDC or CCL22 ?
-
?
monokine induced by IFN-gamma + H2O Homo sapiens i.e. MIg or CXCL9, chemokine ?
-
?
additional information Homo sapiens physiological function of enzyme activities with natural substrates, enzyme is involved in immune regulation, altered enzyme activity and expression level, and diverse physiological effects of increased enzyme expression, in cancer cells, overview, disregulation of the enzyme may contribute to cancer development ?
-
?
NPY + H2O Homo sapiens important step in the neuropeptide-Y NPY-mediated angiogenesis ?
-
?
RANTES + H2O Homo sapiens i.e. CCL5 or regulated on activation normal T-cell expressed and secreted, chemokine ?
-
?
stromal cell derived factor 1 + H2O Homo sapiens i.e. SDF-1 or CXCL12, chemokine ?
-
?
substance P + H2O Homo sapiens i.e. SP, sequential cleavage of full length substance P peptides SP(3-11) + SP(5-11) + ? both fragments are still active ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
basal cell carcinoma cell
-
Homo sapiens
-
hairy cell leukemia cell
-
Homo sapiens
-
hepatocarcinoma cell CD26 Homo sapiens
-
lung adenocarcinoma cell
-
Homo sapiens
-
lymphocyte increased enzyme activity in chronic lymphocytic leukemia Homo sapiens
-
melanocyte
-
Homo sapiens
-
additional information changes in enzyme expression are observed in numerous types of human malignancies as well as in blood plasma of cancer patients Homo sapiens
-
ovarian carcinoma cell overexpression Homo sapiens
-
plasma
-
Homo sapiens
-
prostate tumor cell
-
Homo sapiens
-
T-cell
-
Homo sapiens
-
T-cell leukemia cell
-
Homo sapiens
-
T-cell lymphoma cell
-
Homo sapiens
-
thyroid carcinoma cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
eotaxin + H2O i.e. CCL11, chemokine Homo sapiens ?
-
?
gastrin releasing peptide + H2O sequential cleavage of 2 N-terminal peptides Homo sapiens ?
-
?
glucagon-like peptide 1 + H2O i.e. GLP 1 Homo sapiens ?
-
?
glucagon-like peptide 2 + H2O i.e. GLP 2 Homo sapiens ?
-
?
IFN-gamma-inducible protein 10 + H2O i.e. IP-10 or CXCL10, chemokine Homo sapiens ?
-
?
IFN-inducible T-cell alpha-chemoattractant + H2O i.e. I-TAC or CXCL11, chemokine Homo sapiens ?
-
?
macrophage-derived chemokine + H2O i.e. MDC or CCL22 Homo sapiens ?
-
?
monokine induced by IFN-gamma + H2O i.e. MIg or CXCL9, chemokine Homo sapiens ?
-
?
additional information enzyme binds to adenosine deaminase ADA Homo sapiens ?
-
?
additional information physiological function of enzyme activities with natural substrates, enzyme is involved in immune regulation, altered enzyme activity and expression level, and diverse physiological effects of increased enzyme expression, in cancer cells, overview, disregulation of the enzyme may contribute to cancer development Homo sapiens ?
-
?
NPY + H2O important step in the neuropeptide-Y NPY-mediated angiogenesis Homo sapiens ?
-
?
NPY(1-36) peptide + H2O peptide derived from the neuropeptide-Y Homo sapiens ?
-
?
NPY(3-36) peptide + H2O peptide derived from the neuropeptide-Y Homo sapiens ?
-
?
RANTES + H2O i.e. CCL5 or regulated on activation normal T-cell expressed and secreted, chemokine Homo sapiens ?
-
?
stromal cell derived factor 1 + H2O i.e. SDF-1 or CXCL12, chemokine Homo sapiens ?
-
?
substance P + H2O i.e. SP, sequential cleavage of full length substance P Homo sapiens peptides SP(3-11) + SP(5-11) + ? both fragments are still active ?

Synonyms

Synonyms Comment Organism
CD26
-
Homo sapiens
dipeptidyl peptidase IV
-
Homo sapiens
DPP-IV
-
Homo sapiens
More enzyme belongs to the group of dipeptidylpeptidase-IV activity and/or structure homologues, i.e. DASH Homo sapiens