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Literature summary for 3.4.14.5 extracted from

  • Kuehn-Wache, K.; Hoffmann, T.; Manhart, S.; Brandt, W.; Demuth, H.U.
    The specificity of DP IV for natural substrates is peptide structure determined (2003), Adv. Exp. Med. Biol., 524, 57-63.
    View publication on PubMed
Search for more literature for 3.4.14.5

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glucagon-like peptide 1 + H2O Homo sapiens i.e. GLP-1, incretin, degradation, regulation of activity ?
-
 ?
glucose-dependent insulinotropic polypeptide + H2O Homo sapiens i.e. GIP, incretin ?
-
 ?
additional information Homo sapiens substrate specificty ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline enzyme prefers Ala in P1 position, reduced activity is observed with Ser, Gly, or Val at the P1 position, modeling of reaction mechanism and substrate binding at the catalytic site Homo sapiens
a

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glucagon-like peptide 1 + H2O i.e. GLP-1, incretin, degradation, regulation of activity Homo sapiens ?
-
 ?
glucose-dependent insulinotropic polypeptide + H2O i.e. GIP, incretin Homo sapiens ?
-
 ?
glucose-dependent insulinotropic polypeptide(1-30) peptide + H2O GIP-fragment Homo sapiens ?
-
 ?
glucose-dependent insulinotropic polypeptide(1-42) peptide + H2O GIP-fragment Homo sapiens ?
-
 ?
glucose-dependent insulinotropic polypeptide(1-6) peptide + H2O GIP-fragment, very low activity Homo sapiens ?
-
 ?
additional information substrate specificty Homo sapiens ?
-
 ?
additional information substrate specificty, no activity with glucose-dependent insulinotropic polypeptide(3-42) peptide, [Gly2]glucose-dependent insulinotropic polypeptide(1-6) peptide, and [Val2]glucose-dependent insulinotropic polypeptide(1-6) peptide Homo sapiens ?
-
 ?
[Gly2]glucose-dependent insulinotropic polypeptide(1-30) peptide + H2O GIP-fragment with glycine at position 2 in the sequence Homo sapiens ?
-
 ?
[Ser2]glucose-dependent insulinotropic polypeptide(1-30) peptide + H2O GIP-fragment with serine at position 2 in the sequence Homo sapiens ?
-
 ?
[Ser2]glucose-dependent insulinotropic polypeptide(1-6) peptide + H2O GIP-fragment with serine at position 2 in the sequence Homo sapiens ?
-
 ?
[Val2]glucose-dependent insulinotropic polypeptide(1-30) peptide + H2O GIP-fragment with valine at position 2 in the sequence Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
CD26
-
 Homo sapiens
dipeptidyl peptidase IV
-
 Homo sapiens
DP IV
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
 assay at Homo sapiens