Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | therapeutical perspectives for dipeptidyl peptidase IV inhibitors | Homo sapiens | |
additional information | - |
Mammalia |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mammalia | 16020 | - |
membrane | anchored | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | on human T cells the enzyme has been demonstrated to be a functional collagen receptor leading to cell activation. The enzyme may be important in modulation of the biological activity on some of the cytokines, growth factors and neuropeptides. CD/DPP IV plays a role in HIV infection, but the exact mechanism remains to be elucidated | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mammalia | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-casomorphin + H2O | - |
Homo sapiens | ? | - |
? | |
beta-casomorphin + H2O | Tyr-Pro-/-Phe-Pro-/-Gly | Mammalia | ? | - |
? | |
enterostatin + H2O | i.e. Val-Pro-/-Asn-Pro-/-Arg | Mammalia | ? | - |
? | |
human glucagon-like peptide 1 (7-36) + H2O | i.e. His-Ala-/-Glu-Gly-Thr-Phe-Thr-Ser-Asp | Mammalia | ? | - |
? | |
human glucagon-like peptide 2 + H2O | i.e. His-Ala-/-Asp-Gly-Ser-Phe-Ser-Asp-Glu | Mammalia | ? | - |
? | |
human glucose-dependent insulinotropic polypeptide + H2O | i.e. Tyr-Ala-/-Glu-Gly-Thr-Phe-Thr-Ser-Asp- | Mammalia | ? | - |
? | |
human growth hormone-releasing factor + H2O | i.e. Tyr-Ala-/-Asp-Ala-Ile-Phe-Thr-Asn-Ser- | Mammalia | ? | - |
? | |
human neuropeptide Y + H2O | i.e. Tyr-Pro-/-Ser-Lys-Pro-Asp-Asn-Pro-Gly | Mammalia | Tyr-Pro + Ser-Lys-Pro-Asp-Asn-Pro-Gly | - |
? | |
human peptide YY + H2O | i.e. Tyr-Pro-/-Ile-Lys-Pro-Glu-Ala-Pro-Gly- | Mammalia | Tyr-Pro + Ile-Lys-Pro-Glu-Ala-Pro-Gly- | - |
? | |
additional information | on human T cells the enzyme has been demonstrated to be a functional collagen receptor leading to cell activation. The enzyme may be important in modulation of the biological activity on some of the cytokines, growth factors and neuropeptides. CD/DPP IV plays a role in HIV infection, but the exact mechanism remains to be elucidated | Homo sapiens | ? | - |
? | |
substance P + H2O | - |
Homo sapiens | Arg-Pro + Lys-Pro + ? | - |
? | |
substance P + H2O | Arg-Pro-/-Lys-Pro-/-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 | Mammalia | Arg-Pro + Lys-Pro + ? | - |
? | |
Tyr-Pro-Phe-Pro-NH2 + H2O | i.e. morphiceptin | Mammalia | Tyr-Pro + Phe-Pro-NH2 | - |
? |