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Literature summary for 3.4.14.5 extracted from

  • Fukasawa, K.M.; Fukasawa, K.; Hiraoka, B.Y.; Harada, M.
    Comparison of dipeptidyl peptidase IV prepared from pig liver and kidney (1981), Biochim. Biophys. Acta, 657, 179-189.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
chymotrypsin A strongly activates Sus scrofa
papain strongly activates Sus scrofa

General Stability

General Stability Organism
treatment with trypsin, chymotrypsin A, pronase P and papain decrease the activity of the kidney enzyme Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
diisopropyl fluorophosphate
-
Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Sus scrofa
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
130000
-
x * 130000, SDS-PAGE Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification
-
Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Sus scrofa
-
liver
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Glu-Pro-4-nitroanilide + H2O
-
Sus scrofa Glu-Pro + 4-nitroaniline
-
?
Gly-Pro-4-nitroanilide + H2O
-
Sus scrofa Gly-Pro + 4-nitroaniline
-
?
Lys-Pro-4-nitroanilide + H2O 34% of the activity with Gly-Pro-4-nitroanilide Sus scrofa Lys-Pro + 4-nitroaniline
-
?

Subunits

Subunits Comment Organism
? x * 130000, SDS-PAGE Sus scrofa

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
66
-
kidney enzyme is fairly stable, liver enzyme is rapidly inactivated Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8 8 liver and kidney enzyme Sus scrofa

pH Stability

pH Stability pH Stability Maximum Comment Organism
4.6 11 37°C, 45 min, less than 25% loss of activity, kidney enzyme Sus scrofa
5.8 10 37°C, 45 min, less than 25% loss of activity, liver enzyme Sus scrofa