Literature summary for 3.4.14.4 extracted from

Cvitesic, A.; Sabljic, I.; Makarevic, J.; Abramic, M.
Novel dipeptidyl hydroxamic acids that inhibit human and bacterial dipeptidyl peptidase III (2016), J. Enzyme Inhib. Med. Chem., 31, 40-45 .

Search for more literature for 3.4.14.4

Inhibitors

Inhibitors	Comment	Organism	Structure
H-Phe-Gly-NHOH	competitive	Bacteroides thetaiotaomicron
H-Phe-Gly-NHOH	competitive	Homo sapiens
H-Phe-Leu-NHOH	competitive	Bacteroides thetaiotaomicron
H-Phe-Leu-NHOH	competitive	Homo sapiens
H-Phe-Phe-NHOH	competitive	Bacteroides thetaiotaomicron
H-Phe-Phe-NHOH	competitive	Homo sapiens
H-Tyr-Phe-NHOH	competitive	Bacteroides thetaiotaomicron
H-Tyr-Phe-NHOH	competitive	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Bacteroides thetaiotaomicron	Q8A6N1	-	-
Bacteroides thetaiotaomicron DSM 2079	Q8A6N1	-	-
Homo sapiens	Q9NY33	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Arg-Arg-2-naphthylamide + H2O	-	Homo sapiens	Arg-Arg + 2-naphthylamine	-	?
Arg-Arg-2-naphthylamide + H2O	-	Bacteroides thetaiotaomicron	Arg-Arg + 2-naphthylamine	-	?
Arg-Arg-2-naphthylamide + H2O	-	Bacteroides thetaiotaomicron DSM 2079	Arg-Arg + 2-naphthylamine	-	?

Synonyms

Synonyms	Comment	Organism
BT_1846	-	Bacteroides thetaiotaomicron

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000028	-	H-Phe-Phe-NHOH	pH 7.4, 25°C	Homo sapiens
0.00003	-	H-Tyr-Phe-NHOH	pH 7.4, 25°C	Homo sapiens
0.000049	-	H-Phe-Phe-NHOH	pH 7.4, 25°C	Bacteroides thetaiotaomicron
0.000062	-	H-Tyr-Phe-NHOH	pH 7.4, 25°C	Bacteroides thetaiotaomicron
0.000075	-	H-Phe-Leu-NHOH	pH 7.4, 25°C	Bacteroides thetaiotaomicron
0.00065	-	H-Phe-Leu-NHOH	pH 7.4, 25°C	Homo sapiens
0.000795	-	H-Phe-Gly-NHOH	pH 7.4, 25°C	Bacteroides thetaiotaomicron
0.00463	-	H-Phe-Gly-NHOH	pH 7.4, 25°C	Homo sapiens

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Release 2023.1 (January 2023)