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Literature summary for 3.4.14.4 extracted from

  • Mazzocco, C.; Gillibert-Duplantier, J.; Neaud, V.; Fukasawa, K.M.; Claverol, S.; Bonneu, M.; Puiroux, J.
    Identification and characterization of two dipeptidyl-peptidase III isoforms in Drosophila melanogaster (2006), FEBS J., 273, 1056-1064.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
EGTA 96% inhibition in the presence of 1 mM EGTA, but 110% activity in the presence of the two inhibitors 1 mM EGTA and 1 mM Zn2+ Drosophila melanogaster
tynorphin Val-Val-Tyr-Pro-Trp, 10 microM, 99% inhibition Drosophila melanogaster
Zn2+ 19% inhibition in the presence of 0.1 mM Zn2+, 99.8% inhibition in the presence of 1 mM Zn2+ Drosophila melanogaster

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0045
-
Proctolin
-
Drosophila melanogaster
0.0419
-
Tyr-Gly-Gly-Phe-Met
-
Drosophila melanogaster

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ 516% activity in the presence of 0.1 mM Co2+, 758% activity in the presence of 1 mM Co2+ Drosophila melanogaster

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
82000
-
SDS-PAGE and Western blot Drosophila melanogaster
89000
-
SDS-PAGE and Western blot Drosophila melanogaster

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q9VHR8
-
-

Purification (Commentary)

Purification (Comment) Organism
Hi-Trap Q Sepharose chromatography Drosophila melanogaster

Source Tissue

Source Tissue Comment Organism Textmining
central nervous system in larva Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Arg-Tyr-Leu-Pro-Thr + H2O
-
Drosophila melanogaster Arg-Tyr + Leu-Pro-Thr
-
?
proctolin + H2O
-
Drosophila melanogaster Arg-Tyr + Leu-Pro-Thr
-
?
Tyr-Gly-Gly-Phe-Met + H2O
-
Drosophila melanogaster ?
-
?