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Literature summary for 3.4.14.4 extracted from
- Dipeptidyl peptidase III from human erythrocytes (1988), Biol. Chem. Hoppe-Seyler, 369, 29-38.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | - |
Homo sapiens |  |
| EDTA | - |
Homo sapiens | |
| Ni2+ | - |
Homo sapiens | |
| p-hydroxymercuribenzoate | reactivation by reduced glutathione or mercaptoethanol | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0077 | - |
Arg-Arg-2-naphthylamide | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | increase of activity | Homo sapiens | |
| Zn2+ | slight activation | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 80000 | 86000 | gel filtration | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 21 | - |
- |
Homo sapiens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -10°C, 50 mM sodium phosphate buffer, pH 6.8, 1 mM mercaptoethanol, 0.5 M NaCl, 40% glycerol, 1 year | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Ala-Ala-2-naphthylamide + H2O | - |
Homo sapiens | Ala-Ala + 2-naphthylamine | - |
? | |
| angiotensin II + H2O | - |
Homo sapiens | Asp-Arg + Val-Tyr + Ile-His + Pro-Phe | - |
? | |
| Arg-Arg-2-naphthylamide + H2O | - |
Homo sapiens | Arg-Arg + 2-naphthylamine | - |
? | |
| Met-Arg-Phe-Ala + H2O | - |
Homo sapiens | Met-Arg + Phe-Ala | - |
? | |
| additional information | hydrolysis depending on type of amino acid and chain length | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * ?, SDS-PAGE | Homo sapiens |
| monomer | 1 * ?, PHAST-system gradient PAGE | Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 40 | - |
- |
Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| additional information | - |
sensitive to freezing | Homo sapiens |
| 40 | - |
inactivation above | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.3 | 8 | substrate angiotensin II | Homo sapiens |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 6.7 | 9 | - |
Homo sapiens |
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