Cloned (Comment) | Organism |
---|---|
DNA sequence determination and analysis, sequence contains a leucine zipper motif | Rattus norvegicus |
General Stability | Organism |
---|---|
enzyme is stable during several repeated cycles of freezing and thawing | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-(2-aminoethyl)benzenesulfonyl fluoride | 60% inhibition at 1 mM, preincubation at room temperature for 15 min | Rattus norvegicus | |
benzamidine | 10% inhibition at 1 mM, preincubation at room temperature for 15 min | Rattus norvegicus | |
Cu2+ | 40% inhibition at 1 mM, preincubation at room temperature for 15 min | Rattus norvegicus | |
diisopropylfluorophosphate | complete inhibition at 1 mM, 25% inhibition at 0.1 mM, preincubation at room temperature for 15 min | Rattus norvegicus | |
Hg2+ | complete inhibition at 1 mM, preincubation at room temperature for 15 min | Rattus norvegicus | |
additional information | poor or no inhibition by EDTA, NEM, E-64, diprotin A, and actinonin | Rattus norvegicus | |
PCMBS | 77% inhibition at 1 mM, preincubation at room temperature for 15 min | Rattus norvegicus | |
PMSF | 45% inhibition at 1 mM, preincubation at room temperature for 15 min | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Rattus norvegicus | 5764 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
54054 | - |
2 * 54054, mass spectrometry | Rattus norvegicus |
105000 | - |
gel filtration and native PAGE | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
131.3fold to homogeneity, from kidney | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Rattus norvegicus | - |
brain | - |
Rattus norvegicus | - |
cerebellum | - |
Rattus norvegicus | - |
cerebrum | - |
Rattus norvegicus | - |
epididymis | - |
Rattus norvegicus | - |
esophagus | - |
Rattus norvegicus | - |
heart | - |
Rattus norvegicus | - |
kidney | - |
Rattus norvegicus | - |
large intestine | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
lung | - |
Rattus norvegicus | - |
additional information | tissue distribution, overview | Rattus norvegicus | - |
muscle | - |
Rattus norvegicus | - |
pancreas | - |
Rattus norvegicus | - |
prostate | - |
Rattus norvegicus | - |
skeletal muscle | - |
Rattus norvegicus | - |
small intestine | - |
Rattus norvegicus | - |
spermatozoon | - |
Rattus norvegicus | - |
spleen | - |
Rattus norvegicus | - |
stomach | - |
Rattus norvegicus | - |
testis | - |
Rattus norvegicus | - |
thymus | - |
Rattus norvegicus | - |
trachea | - |
Rattus norvegicus | - |
urinary bladder | - |
Rattus norvegicus | - |
uterus | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.3 | - |
purified enzyme, substrate Ala-Ala-2-nitroanilide | Rattus norvegicus |
1.05 | - |
purified enzyme, substrate Lys-Ala-7-amido-4-methylcoumarin | Rattus norvegicus |
2.11 | - |
purified enzyme, substrate Gly-Pro-7-amido-4-methylcoumarin | Rattus norvegicus |
2.85 | - |
purified enzyme, substrate Ala-Pro-amino-4-trifluoromethylcoumarin | Rattus norvegicus |
Storage Stability | Organism |
---|---|
-30°C, 20 mM sodium phosphate-buffered saline, pH 8.0, stable for at least several months | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ala-Ala-2-nitroanilide + H2O | low activity | Rattus norvegicus | Ala-Ala + 2-nitroaniline | - |
? | |
Ala-Pro-amino-4-trifluoromethylcoumarin + H2O | - |
Rattus norvegicus | Ala-Pro + amino-4-trifluoromethylcoumarin | - |
? | |
Gly-Pro-7-amido-4-methylcoumarin + H2O | - |
Rattus norvegicus | Gly-Pro + 7-amino-4-methylcoumarin | - |
? | |
Lys-Ala-7-amido-4-methylcoumarin + H2O | - |
Rattus norvegicus | Lys-Ala + 7-amino-4-methylcoumarin | - |
? | |
additional information | substrate specificity | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 54054, mass spectrometry | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
More | enzyme belongs to the Pro-X carboxypeptidase family S28 | Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
30 min, stable up to | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | - |
with substrate Lys-Ala-7-amido-4-methylcoumarin | Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
2.5 | 11.5 | - |
Rattus norvegicus |