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Literature summary for 3.4.14.14 extracted from

  • Ayikpoe, R.; Govindarajan, V.; Latham, J.A.
    Occurrence, function, and biosynthesis of mycofactocin (2019), Appl. Microbiol. Biotechnol., 103, 2903-2912 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.14.14

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ iron-dependent peptidase Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
precursor peptide MftA-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + H2O Mycobacterium tuberculosis the enzyme selectively hydrolyzes the amide bond between Val29 and Gly28 of MftA*, liberating the putative carbon skeleton of mycofactocin, 3-amino-5-[(p-hydroxyphenyl) methyl]-4,4-dimethyl-2-pyrrolidinone MftA(1-28) + 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidinone
-
 ?
precursor peptide MftA-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + H2O Mycobacterium tuberculosis H37Rv the enzyme selectively hydrolyzes the amide bond between Val29 and Gly28 of MftA*, liberating the putative carbon skeleton of mycofactocin, 3-amino-5-[(p-hydroxyphenyl) methyl]-4,4-dimethyl-2-pyrrolidinone MftA(1-28) + 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidinone
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WP59
-
-
Mycobacterium tuberculosis H37Rv P9WP59
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
precursor peptide MftA-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + H2O the enzyme selectively hydrolyzes the amide bond between Val29 and Gly28 of MftA*, liberating the putative carbon skeleton of mycofactocin, 3-amino-5-[(p-hydroxyphenyl) methyl]-4,4-dimethyl-2-pyrrolidinone Mycobacterium tuberculosis MftA(1-28) + 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidinone
-
 ?
precursor peptide MftA-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + H2O the enzyme selectively hydrolyzes the amide bond between Val29 and Gly28 of MftA*, liberating the putative carbon skeleton of mycofactocin, 3-amino-5-[(p-hydroxyphenyl) methyl]-4,4-dimethyl-2-pyrrolidinone Mycobacterium tuberculosis H37Rv MftA(1-28) + 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidinone
-
 ?

Synonyms

Synonyms Comment Organism
mftE
-
 Mycobacterium tuberculosis
Rv0695
-
 Mycobacterium tuberculosis