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Literature summary for 3.4.14.11 extracted from
- The structural comparison of the bacterial PepX and human DPP-IV reveals sites for the design of inhibitors of PepX activity (2005), FEBS J., 272, 2050-2059.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Diprotin A | IC50: 0.26 mM | Lactococcus lactis |  |
| Diprotin B | IC50: 0.6 mM | Lactococcus lactis | |
| Val-pyrrolidide | IC50: 0.03 mM | Lactococcus lactis | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Lactococcus lactis | P22346 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Ala-Pro-4-nitroanilide + H2O | - |
Lactococcus lactis | Ala-Pro + 4-nitroaniline | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PepX | - |
Lactococcus lactis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
- |
Lactococcus lactis |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.03 | - |
IC50: 0.03 mM | Lactococcus lactis | Val-pyrrolidide | |
| 0.26 | - |
IC50: 0.26 mM | Lactococcus lactis | Diprotin A | |
| 0.6 | - |
IC50: 0.6 mM | Lactococcus lactis | Diprotin B | |
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Release 2023.1 (January 2023)
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