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Literature summary for 3.4.14.10 extracted from

  • Fukuda, Y.; Beck, F.; Plitzko, J.M.; Baumeister, W.
    In situ structural studies of tripeptidyl peptidase II (TPPII) reveal spatial association with proteasomes (2017), Proc. Natl. Acad. Sci. USA, 114, 4412-4417 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q64560
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Source Tissue

Source Tissue Comment Organism Textmining
hippocampus
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 Rattus norvegicus
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neuron
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 Rattus norvegicus
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General Information

General Information Comment Organism
physiological function TPPII, assembles to form a spindle-shaped complex of about 6 MDa. Dependent on protein concentration, TPPII has a distinct tendency for polymorphism. Two different assembly states (36-mers and 32-mers) coexist as well as occasional extended forms with longer strands. TPPII and 26S proteasomes spatially associate in agreement with TPPII's role in postproteasomal degradation Rattus norvegicus