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Literature summary for 3.4.14.10 extracted from

  • Wiemhoefer, A.; Stargardt, A.; van der Linden, W.A.; Renner, M.C.; van Kesteren, R.E.; Stap, J.; Raspe, M.A.; Tomkinson, B.; Kessels, H.W.; Ovaa, H.; Overkleeft, H.S.; Florea, B.; Reits, E.A.
    Tripeptidyl peptidase II mediates levels of nuclear phosphorylated ERK1 and ERK2 (2015), Mol. Cell. Proteomics, 14, 2177-2193 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
butabindide reversible Homo sapiens
diphenyl [1-([1-[(2S)-2-aminobutanoyl]-2,3-dihydro-1H-indole-2-carbonyl]amino)-3-methylbutyl]phosphonate irreversible variant of butabindide. almost 60fold more potent than butabindide Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P29144
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
TPP2
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00000046
-
 pH 7.5, 37°C Homo sapiens diphenyl [1-([1-[(2S)-2-aminobutanoyl]-2,3-dihydro-1H-indole-2-carbonyl]amino)-3-methylbutyl]phosphonate

General Information

General Information Comment Organism
physiological function TPP2 inhibition indirectlybut rapidly decreases the levels of active, diphosphorylated extracellular signal-regulated kinase ERK1 and ERK2 in the nucleus, thereby down-regulating signal transduction downstream of growth factors and mitogenic stimuli. TPP2 inhibition of neurons in the hippocampus leads to an excessive strengthening of synapses Homo sapiens