Literature summary for 3.4.14.10 extracted from

Bialy, L.P.; Kuckelkorn, U.; Henklein, P.; Fayet, J.; Wilczynski, G.M.; Kaminski, A.; Mlynarczuk-Bialy, I.
Changes in spatio-temporal localization of tripeptidyl peptidase II (TPPII) in murine colon adenocarcinoma cells during aggresome formation a microscopy study based on a novel fluorescent proteasome inhibitor (2019), Histol. Histopathol., 34, 359-372 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Colon-26 cell	murine colon adenocarcinoma cell	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	in the absence of proteasome inhibitor BSc2118, TPPII is diffusely dispersed within the cytoplasm of C-26 colon adenocarcinoma cells. The proteasome and ubiquitin-rich perinuclear region do not display enhanced TPPII staining. When proteasome function is impaired by the inhibitor, TPPII associates more closely with both the proteasome and polyubiquitinated. TPPII is dynamically recruited into the developing aggresome: TPPII in the early aggresome is dispersed within the central part but subsequently aggregated on the surface of this structure	Mus musculus

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Release 2023.1 (January 2023)