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Literature summary for 3.4.14.10 extracted from

  • Zhou, Y.; Ru, Y.; Wang, C.; Wang, S.; Zhou, Z.; Zhang, Y.
    Tripeptidyl peptidase II regulates sperm function by modulating intracellular Ca(2+) stores via the ryanodine receptor (2013), PLoS ONE, 8, e66634.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine isoform TPPII can regulate sperm maturation by modulating intracellular Ca2+ stores via the type 3 ryanodine receptor. Tripeptidyl peptidase II antagonists strongly activate the cAMP/PKA signaling pathway that drives sperm capacitation-associated protein tyrosine phosphorylation. In the absence of Ca2+, TPPII antagonists elevate the intracellular Ca2+ levels in sperm, resulting in a marked improvement in sperm movement, capacitation, acrosome reaction, and the in vitro fertilizing ability. This antagonist-induced release of intracellular Ca2+ can be blocked by the inhibitors of ryanodine receptors which are the main intracellular Ca2+ channels responsible for releasing stored Ca2+ Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Mus musculus Q64514
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-

Source Tissue

Source Tissue Comment Organism Textmining
spermatozoon TPPII is located on the sperm acrosomal region Mus musculus
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testis
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Mus musculus
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Synonyms

Synonyms Comment Organism
TPP II
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Mus musculus
tripeptidyl aminopeptidase I
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Mus musculus

General Information

General Information Comment Organism
physiological function isoform TPPII can regulate sperm maturation by modulating intracellular Ca2+ stores via the type 3 ryanodine receptor. Tripeptidyl peptidase II antagonists strongly activate the cAMP/PKA signaling pathway that drives sperm capacitation-associated protein tyrosine phosphorylation. In the absence of Ca2+, TPPII antagonists elevate the intracellular Ca2+ levels in sperm, resulting in a marked improvement in sperm movement, capacitation, acrosome reaction, and the in vitro fertilizing ability. This antagonist-induced release of intracellular Ca2+ can be blocked by the inhibitors of ryanodine receptors which are the main intracellular Ca2+ channels responsible for releasing stored Ca2+ Mus musculus
physiological function TPP II is involved in the fertilization process. The increased intercellular Ca2+ level induced by TPPII antagonists via RyR3 (ryanodine receptor) represents a mechanism of activation of sperm Mus musculus