Application | Comment | Organism |
---|---|---|
medicine | isoform TPPII can regulate sperm maturation by modulating intracellular Ca2+ stores via the type 3 ryanodine receptor. Tripeptidyl peptidase II antagonists strongly activate the cAMP/PKA signaling pathway that drives sperm capacitation-associated protein tyrosine phosphorylation. In the absence of Ca2+, TPPII antagonists elevate the intracellular Ca2+ levels in sperm, resulting in a marked improvement in sperm movement, capacitation, acrosome reaction, and the in vitro fertilizing ability. This antagonist-induced release of intracellular Ca2+ can be blocked by the inhibitors of ryanodine receptors which are the main intracellular Ca2+ channels responsible for releasing stored Ca2+ | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus | Q64514 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
spermatozoon | TPPII is located on the sperm acrosomal region | Mus musculus | - |
testis | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
TPP II | - |
Mus musculus |
tripeptidyl aminopeptidase I | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | isoform TPPII can regulate sperm maturation by modulating intracellular Ca2+ stores via the type 3 ryanodine receptor. Tripeptidyl peptidase II antagonists strongly activate the cAMP/PKA signaling pathway that drives sperm capacitation-associated protein tyrosine phosphorylation. In the absence of Ca2+, TPPII antagonists elevate the intracellular Ca2+ levels in sperm, resulting in a marked improvement in sperm movement, capacitation, acrosome reaction, and the in vitro fertilizing ability. This antagonist-induced release of intracellular Ca2+ can be blocked by the inhibitors of ryanodine receptors which are the main intracellular Ca2+ channels responsible for releasing stored Ca2+ | Mus musculus |
physiological function | TPP II is involved in the fertilization process. The increased intercellular Ca2+ level induced by TPPII antagonists via RyR3 (ryanodine receptor) represents a mechanism of activation of sperm | Mus musculus |