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Literature summary for 3.4.14.10 extracted from

  • Nahalkova, J.; Tomkinson, B.
    TPPII, MYBBP1A and CDK2 form a protein-protein interaction network (2014), Arch. Biochem. Biophys., 564, 128-135.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
butabindide
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-
K-562 cell
-
Homo sapiens
-

General Information

General Information Comment Organism
physiological function isoform TPPII physically interacts with the tumor suppressor MYBBP1A and the cell cycle regulator protein CDK2. HEK-293 cells overexpressing TPPII form highly enzymatically active oligomeric complexes, and the cytoplasmic interaction frequency of TPPII with MYBBP1A increases with the protein expression of TPPII in serum-free cell growth conditions. A specific reversible inhibitor of TPPII, butabindide, suppresses the cytoplasmic interactions of TPPII and MYBBP1A both in control HEK-293 and cells overexpressing murine TPPII. A gene expression study during anoikis shows that overexpression of TPP II decreases mRNA expression level of MYBBP1A at the cell detachment conditions Homo sapiens