Inhibitors | Comment | Organism | Structure |
---|---|---|---|
butabindide | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
K-562 cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | isoform TPPII physically interacts with the tumor suppressor MYBBP1A and the cell cycle regulator protein CDK2. HEK-293 cells overexpressing TPPII form highly enzymatically active oligomeric complexes, and the cytoplasmic interaction frequency of TPPII with MYBBP1A increases with the protein expression of TPPII in serum-free cell growth conditions. A specific reversible inhibitor of TPPII, butabindide, suppresses the cytoplasmic interactions of TPPII and MYBBP1A both in control HEK-293 and cells overexpressing murine TPPII. A gene expression study during anoikis shows that overexpression of TPP II decreases mRNA expression level of MYBBP1A at the cell detachment conditions | Homo sapiens |