Literature summary for 3.4.14.1 extracted from

Makowski, M.; Lenartowicz, P.; Oszywa, B.; Jewginski, M.; Pawelczak, M.; Kafarski, P.
Synthesis of dehydrodipeptide esters and their evaluation as inhibitors of cathepsin C (2015), Med. Chem. Res., 24, 3157-3165 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
molecular modeling of inhibitor docking. Esters of dehydropeptides containing C-terminal (Z)-dehydrophenylalanine and dehydroalanine appear to be moderate or weak inhibitors of cathepsin C, with some of them exhibiting slow-binding behavior. They are rather bind at the surface of the enzyme and are not submersed in its binding cavities	Bos taurus

Inhibitors

Inhibitors	Comment	Organism	Structure
3-chloro-2-hydroxypropyl (2Z)-2-(2-aminoacetamido)-3-phenylprop-2-enoate	-	Bos taurus
prop-2-en-1-yl 2-(2-amino-3-phenylpropanamido)prop-2-enoate	-	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	Q3ZCJ8	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
spleen	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
glycine-L-phenylalanine-p-nitroanilide + H2O	-	Bos taurus	glycine-L-phenylalanine + p-nitroaniline	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0055	-	3-chloro-2-hydroxypropyl (2Z)-2-(2-aminoacetamido)-3-phenylprop-2-enoate	pH 5.0, 37°C	Bos taurus
0.017	-	prop-2-en-1-yl 2-(2-amino-3-phenylpropanamido)prop-2-enoate	pH 5.0, 37°C	Bos taurus

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Release 2023.1 (January 2023)