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Literature summary for 3.4.14.1 extracted from

  • Hamon, Y.; Legowska, M.; Herve, V.; Dallet-Choisy, S.; Marchand-Adam, S.; Vanderlynden, L.; Demonte, M.; Williams, R.; Scott, C.J.; Si-Tahar, M.; Heuze-Vourch, N.; Lalmanach, G.; Jenne, D.E.; Lesner, A.; Gauthier, F.; Korkmaz, B.
    Neutrophilic cathepsin C is maturated by a multistep proteolytic process and secreted by activated cells during inflammatory lung diseases (2016), J. Biol. Chem., 291, 8486-8499 .
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm HL-60 cells and differentiated neutrophil-like cells show active CatC in cytoplasmic granules Homo sapiens 5737
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Golgi apparatus mainly located in the Golgi of granule-free undifferentiated PLB-985 cells Homo sapiens 5794
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Organism

Organism UniProt Comment Textmining
Homo sapiens P53634
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
PLB-985 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gly-Phe-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Gly-Phe + 7-amino-4-methylcoumarin
-
 ?

General Information

General Information Comment Organism
physiological function the maturation of proCatC obeys a multistep mechanism that can be entirely managed by CatS in neutrophilic precursor cells. CatS inhibition by a cell-permeable inhibitor abrogates the release of the heavy and light chains from proCatC and blocks 80% of CatC activity. Under these conditions, the activity of neutrophil serine proteases is not abolished in precursor cell cultures Homo sapiens