Literature summary for 3.4.14.1 extracted from

Wei, S.; Wang, S.; Yang, M.; Huang, Y.; Wei, J.; Huang, X.; Qin, Q.
Characterization of cathepsin C from orange-spotted grouper, Epinephelus coioides involved in SGIV infection (2019), Fish Shellfish Immunol., 84, 423-433 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Epinephelus coioides	5737	-

Organism

Organism	UniProt	Comment	Textmining
Epinephelus coioides	A0A088BPG5	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	sequence contains a N-terminal signal peptide, the propeptide region and the mature peptide	Epinephelus coioides

Source Tissue

Source Tissue	Comment	Organism	Textmining
head kidney	abundant expression in spleen and head kidney	Epinephelus coioides	-
additional information	transcript is expressed in all the examined tissues	Epinephelus coioides	-
spleen	abundant expression in spleen and head kidney	Epinephelus coioides	-

Expression

Organism	Comment	Expression
Epinephelus coioides	the relative expression of EC-CC significantly increases at 24 h post-infection after challenge with Singapore grouper iridovirus	up

General Information

General Information	Comment	Organism
physiological function	overexpression of cathepsin C in vitro significantly delays the cytopathic effect evoked by Singapore grouper iridovirus and inhibit the viral genes transcription. Overexpression significantly increases the expression of proinflammatory cytokines during Singapore grouper iridovirus infection	Epinephelus coioides

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Release 2023.1 (January 2023)