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Literature summary for 3.4.14.1 extracted from

  • Suban, D.; Zajc, T.; Renko, M.; Turk, B.; Turk, V.; Dolenc, I.
    Cathepsin C and plasma glutamate carboxypeptidase secreted from Fischer rat thyroid cells liberate thyroxin from the N-terminus of thyroglobulin (2012), Biochimie, 94, 719-726.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
culture fluid secretion of active enzyme is stimulated by thyrotropin, insulin, and/or somatostatin Rattus norvegicus
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FRTL-5 cell
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Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thyroglobulin + H2O
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Rattus norvegicus ? enzyme removes up to 12 amino acids from the N-terminus of porcine thyroglobulin, including a dipeptide with thyroxin on position 5. The newly formed N-terminus, Arg-Pro-, is not hydrolysed further ?

Synonyms

Synonyms Comment Organism
CATC
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Rattus norvegicus
cathepsin C
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Rattus norvegicus