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Literature summary for 3.4.14.1 extracted from

  • McDonald, J.K.; Zeitman, B.B.; Callahan, P.X.; Ellis, S.
    Angiotensinase activity of dipeptidyl aminopeptidase I (cathepsin C) of rat liver (1974), J. Biol. Chem., 249, 234-240.
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.31
-
 alpha-Asp-Arg-2-naphthylamide
-
 Rattus norvegicus
0.34
-
 Ile5-angiotensin II
-
 Rattus norvegicus
0.44
-
 Asn1-angiotensin II
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-Asp-Arg-2-naphthylamide + H2O
-
 Rattus norvegicus alpha-Asp-Arg + 2-naphthylamine
-
 ?
alpha-D-Asp1-angiotensin II + H2O low reaction rate Rattus norvegicus ?
-
 ?
Asn1-angiotensin II + H2O
-
 Rattus norvegicus ?
-
 ?
beta-Asp1-angiotensin II + H2O low reaction rate Rattus norvegicus ?
-
 ?
Ile5-angiotensin II + H2O
-
 Rattus norvegicus ?
-
 ?
additional information
-
 Rattus norvegicus ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
87
-
 Asn1-angiotensin II removal of the first dipeptide Rattus norvegicus
87
-
 Ile5-angiotensin II removal of the first dipeptide Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5 6 Asn1-angiotensin II or Ile5-angiotensin II as substrate Rattus norvegicus