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Literature summary for 3.4.13.9 extracted from

  • Akcakoyun, M.; Pala, S.; Esen, O.; Acar, G.; Kargin, R.; Emiroglu, Y.; Tigen, K.; Ozcan, O.; Ipcioglu, O.M.; Esen, A.M.
    Dilatation of the ascending aorta is associated with low serum prolidase activity (2010), Tohoku J. Exp. Med., 220, 273-277.
    View publication on PubMed
Search for more literature for 3.4.13.9

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ activates Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta enzyme activity is increased in aortic dilatation compared to controls Homo sapiens
-
serum
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 prolidase activity in correlation to aorta diameter, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gly-L-Pro + H2O
-
 Homo sapiens Gly + L-Pro
-
 ?
additional information prolidase is an exopeptidase cleaving C-terminally proline and hydroxyproline from iminodipeptides Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
prolidase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme activity is increased in aortic dilatation compared to controls Homo sapiens
metabolism prolidase catalyzes the final step of collgane breakdown, releasing free proline for collagen recycling Homo sapiens
physiological function prolidase activity may be a step-limiting factor in the regulation of collagen biosynthesis Homo sapiens