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Literature summary for 3.4.13.9 extracted from

  • Horoz, M.; Aslan, M.; Bolukbas, F.F.; Bolukbas, C.; Nazligul, Y.; Celik, H.; Aksoy, N.
    Serum prolidase enzyme activity and its relation to histopathological findings in patients with non-alcoholic steatohepatitis (2010), J. Clin. Lab. Anal., 24, 207-211.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.13.9

Application

Application Comment Organism
diagnostics prolidase activity may be a useful adjunctive tool in predicting liver fibrosis, especially in the absence of advanced fibrosis and other conditions, which may affect the interpretation of prolidase activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ required Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens
-
 patients with non-alcoholic steatohepatitis
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-
serum enzyme activity is increased in patients with nonalcoholic steatohepatitis, NASH, compared to controls Homo sapiens
-
serum serum prolidase enzyme activity is significantly higher in patients with non-alcoholic steatohepatitis than controls Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information prolidase is a manganese-requiring homodimeric iminodipeptidase, which releases carboxy-terminal proline or hydroxyproline from oligopeptides Homo sapiens ?
-
 ?
additional information prolidase is an iminodipeptidase, which releases C-terminal proline or hydroxyproline from oligopeptides Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
homodimer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
prolidase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme activity is increased in patients with nonalcoholic steatohepatitis, NASH, compared to controls, significant correlation between serum prolidase enzyme activity and fibrosis score in patients with NASH Homo sapiens