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Literature summary for 3.4.13.9 extracted from

  • Lupi, A.; Rossi, A.; Vaghi, P.; Gallanti, A.; Cetta, G.; Forlino, A.
    N-benzyloxycarbonyl-L-proline: An in vitro and in vivo inhibitor of prolidase (2005), Biochim. Biophys. Acta, 1744, 157-163.
    View publication on PubMed
Search for more literature for 3.4.13.9

Inhibitors

Inhibitors Comment Organism Structure
N-Benzyloxycarbonyl-L-proline 90% inhibition after incubation of cell extracts at a 1:1 ratio of inhibitor to substrate Gly-L-Pro. Long-term incubation of fibroblasts with inhibitor causes mitochondria depolarization and increased cellular death Homo sapiens
N-Benzyloxycarbonyl-L-proline daily injection of inhibitor for 3 weeks results in significant reduction of enzyme activity in erythrocyte. Inhibitor is not degraded in vivo Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Mus musculus
-
fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gly-L-Pro + H2O
-
 Mus musculus Gly + L-Pro
-
 ?
Gly-L-Pro + H2O
-
 Homo sapiens Gly + L-Pro
-
 ?