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Literature summary for 3.4.13.9 extracted from

  • Wang, W.; Liu, G.; Yamashita, K.; Manabe, M.; Kodama, H.
    Characteristics of prolinase against various iminodipeptides in erythrocyte lysates from a normal human and a patient with prolidase deficiency (2004), Clin. Chem. Lab. Med., 42, 1102-1108.
    View publication on PubMed
Search for more literature for 3.4.13.9

Activating Compound

Activating Compound Comment Organism Structure
glycine activation of activity against substrates L-Pro-L-Ala, L-Pro-L-Val, L-Pro-L-Met, and L-Pro-L-Asp Homo sapiens
MnCl2 stimulation of activity against substrates L-Pro-Gly, L-Pro-L-Glu, L-Pro-L-Leu, L-Pro-L-Ser, and L-Pro-L-Phe, inhibitory to hydrolysis of substrates L-Pro-L-Ala, L-Pro-L-Val, L-Pro-L-Met, and L-Pro-L-Asp Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.2
-
 L-Pro-L-Val pH 7.8, 37°C, presence of 20 mM glycine, enzyme from patient with enzyme deficiency Homo sapiens
4.2
-
 L-Pro-L-Met pH 7.8, 37°C, presence of 20 mM glycine, enzyme from patient with enzyme deficiency Homo sapiens
5
-
 L-Pro-L-Met pH 7.8, 37°C, presence of 0.1 mM MnCl2 plus 20 mM glycine, enzyme from patient with enzyme deficiency Homo sapiens
5.5
-
 L-Pro-L-Val pH 7.8, 37°C, presence of 0.1 mM MnCl2 plus 20 mM glycine, enzyme from patient with enzyme deficiency Homo sapiens
6.8
-
 L-Pro-Gly pH 7.8, 37°C, presence of 0.1 mM MnCl2 plus 20 mM glycine Homo sapiens
7.9
-
 L-Pro-L-Val pH 7.8, 37°C, enzyme from patient with enzyme deficiency Homo sapiens
8.1
-
 L-Pro-L-Met pH 7.8, 37°C, enzyme from patient with enzyme deficiency Homo sapiens
8.35
-
 L-Pro-L-Met pH 7.8, 37°C, presence of 20 mM glycine Homo sapiens
8.6
-
 L-Pro-Gly pH 7.8, 37°C, presence of 0.1 mM MnCl2 plus 20 mM glycine, enzyme from patient with enzyme deficiency Homo sapiens
9.7
-
 L-Pro-Gly pH 7.8, 37°C, presence of 0.1 mM MnCl2, enzyme from patient with enzyme deficiency Homo sapiens
9.7
-
 L-Pro-L-Met pH 7.8, 37°C, presence of 0.1 mM MnCl2, enzyme from patient with enzyme deficiency Homo sapiens
9.9
-
 L-Pro-L-Met pH 7.8, 37°C, presence of 0.1 mM MnCl2 plus 20 mM glycine Homo sapiens
10.1
-
 L-Pro-L-Val pH 7.8, 37°C, presence of 0.1 mM MnCl2, enzyme from patient with enzyme deficiency Homo sapiens
13.8
-
 L-Pro-Gly pH 7.8, 37°C, presence of 0.1 mM MnCl2 Homo sapiens
14.7
-
 L-Pro-L-Val pH 7.8, 37°C, presence of 20 mM glycine Homo sapiens
15.1
-
 L-Pro-Gly pH 7.8, 37°C, presence of 20 mM glycine Homo sapiens
16.7
-
 L-Pro-Gly pH 7.8, 37°C, presence of 20 mM glycine, enzyme from patient with enzyme deficiency Homo sapiens
17.3
-
 L-Pro-L-Val pH 7.8, 37°C, presence of 0.1 mM MnCl2 plus 20 mM glycine Homo sapiens
17.6
-
 L-Pro-L-Met pH 7.8, 37°C Homo sapiens
18.2
-
 L-Pro-Gly pH 7.8, 37°C, enzyme from patient with enzyme deficiency Homo sapiens
19.1
-
 L-Pro-L-Met pH 7.8, 37°C, presence of 0.1 mM MnCl2 Homo sapiens
26
-
 L-Pro-L-Val pH 7.8, 37°C Homo sapiens
26.9
-
 L-Pro-Gly pH 7.8, 37°C Homo sapiens
28.6
-
 L-Pro-L-Val pH 7.8, 37°C, presence of 0.1 mM MnCl2 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 comparison of normal human and a patient with prolidase deficiency
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Pro-Gly + H2O
-
 Homo sapiens L-Pro + Gly
-
 ?
L-Pro-L-Ala + H2O
-
 Homo sapiens L-Pro + L-Ala
-
 ?
L-Pro-L-Asp + H2O
-
 Homo sapiens L-Pro + L-Asp
-
 ?
L-Pro-L-Glu + H2O
-
 Homo sapiens L-Pro + L-Glu
-
 ?
L-Pro-L-Leu + H2O
-
 Homo sapiens L-Pro + L-Leu
-
 ?
L-Pro-L-Met + H2O
-
 Homo sapiens L-Pro + L-Met
-
 ?
L-Pro-L-Phe + H2O
-
 Homo sapiens L-Pro + L-Phe
-
 ?
L-Pro-L-Ser + H2O
-
 Homo sapiens L-Pro + L-Ser
-
 ?
L-Pro-L-Val + H2O
-
 Homo sapiens L-Pro + L-Val
-
 ?