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Literature summary for 3.4.13.5 extracted from
- Similarity of tuna N-acetylhistidine deacetylase and cod fish anserinase (1978), Comp. Biochem. Physiol. B, 61, 253-258.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-mercaptoethanol | - |
Katsuwonus pelamis |  |
| Chloropromazine | - |
Katsuwonus pelamis | |
| dithiothreitol | - |
Katsuwonus pelamis | |
| EDTA | restored by Zn2+ and Co2+ | Katsuwonus pelamis | |
| Hg2+ | HgCl2 | Katsuwonus pelamis | |
| PCMB | - |
Katsuwonus pelamis | |
| phenylmethylsulfonyl fluoride | - |
Katsuwonus pelamis | |
| phosphate | - |
Katsuwonus pelamis | |
| Trifluorperazine | - |
Katsuwonus pelamis | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | activates | Katsuwonus pelamis | |
| Zn2+ | activates | Katsuwonus pelamis | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Katsuwonus pelamis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Katsuwonus pelamis |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | very rich source | Katsuwonus pelamis | - |
| gall bladder | trace amounts | Katsuwonus pelamis | - |
| intestine | moderate activity | Katsuwonus pelamis | - |
| liver | moderate activity | Katsuwonus pelamis | - |
| ovary | trace amounts | Katsuwonus pelamis | - |
| spleen | trace amounts | Katsuwonus pelamis | - |
| stomach | trace amounts | Katsuwonus pelamis | - |
| vitreous humor | very rich source | Katsuwonus pelamis | - |
| white muscle | trace amounts | Katsuwonus pelamis | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.175 | - |
- |
Katsuwonus pelamis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| anserine + H2O | 9% of the activity with carnosine | Katsuwonus pelamis | beta-Ala + 1-methylhistidine | - |
? | |
| carnosine + H2O | - |
Katsuwonus pelamis | ? | - |
? | |
| Gly-His + H2O | 68% of the activity with carnosine | Katsuwonus pelamis | Gly + His | - |
? | |
| Gly-L-Leu + H2O | 42% of the activity with carnosine | Katsuwonus pelamis | Gly + L-Leu | - |
? | |
| homocarnosine + H2O | 102% of the activity with carnosine | Katsuwonus pelamis | ? | - |
? | |
| N-acetyl-L-His + H2O | 62% of the activity with carnosine | Katsuwonus pelamis | His + acetate | - |
? | |
| N-acetyl-L-methionine + H2O | 12% of the activity with carnosine | Katsuwonus pelamis | L-Met + acetate | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
maximal stability at 30°C, pH 4.7-6.4, in presence of ZnSO4 | Katsuwonus pelamis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 7 | - |
Katsuwonus pelamis |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.2 | 8.5 | 50% of maximal activity at pH 5.2 and at pH 8.5 | Katsuwonus pelamis |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 4 | - |
unstable at | Katsuwonus pelamis |
| 4.7 | 6.4 | maximal stability at 30°C, pH 4.7-6.4, in presence of ZnSO4 | Katsuwonus pelamis |
| 8.5 | - |
unstable at | Katsuwonus pelamis |
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