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Literature summary for 3.4.13.20 extracted from
- Relevance of allosteric conformations and homocarnosine concentration on carnosinase activity (2010), Amino Acids, 38, 1607-1615.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| homocarnosine | - |
Homo sapiens |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.175 | - |
carnosine | Vmax: 440 pmol/min/microgram | Homo sapiens | |
| 0.21 | - |
carnosine | Vmax: 356 pmol/min/microgram after addition of 0.08 mM homocarnosine | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 65000 | - |
SDS-PAGE, non-reducing conditions | Homo sapiens |
| 130000 | - |
SDS-PAGE, reducing conditions | Homo sapiens |
| 150000 | - |
SDS-PAGE, non-reducing conditions or reducing conditions | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cerebrospinal fluid | CN1 activity is considerably higher in serum than in cerebrospinal fluid | Homo sapiens | - |
| serum | CN1 activity is considerably higher in serum than in cerebrospinal fluid | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| carnosine + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 65000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| carnosinase | - |
Homo sapiens |
| CN1 | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.24 | - |
homocarnosine | - |
Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | CN1 activity is lower in children and increases with age with no differences in protein concentration. CN1 activity is considerably higher in serum than in cerebrospinal fluid | Homo sapiens |
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Release 2023.1 (January 2023)
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