Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.13.19 extracted from

  • Nitani, Y.; Satow, Y.; Adachi, H.; Tsujimoto, M.
    Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis (2002), J. Mol. Biol., 321, 177-184.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Cilastatin
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane bound to Homo sapiens 16020
-
microvillus the active site faces towards the microvillar membrane of a kidney tubule Homo sapiens 5902
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc the active site in each of the (alpha/beta)8 barrel subunits of the homodimer molecule is composed of binuclear zinc ions bridged by the Glu125 side-chain located at the bottom of the barrel Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
kidney tubule Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics Homo sapiens ?
-
?