Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin II + H2O | Rattus norvegicus | - |
angiotensin III + L-Asp | - |
? | |
angiotensin II + H2O | Rattus norvegicus Wistar | - |
angiotensin III + L-Asp | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P15684 | - |
- |
Rattus norvegicus Wistar | P15684 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | while hyperthyroid rats exhibit lower levels of plasma AP A activity than controls, the kidney of hyperthyroid animals expresses significantly higher AP A than controls and hypothyroid animals. A discrepancy between the high expression of AP A in kidney of hyperthyroid rats and the low activity of AP A measured in plasma and kidney of hyperthyroid animals is found. The posttranslational influence of environmental biochemical factors may be in part responsible for that divergence | Rattus norvegicus | - |
kidney | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin II + H2O | - |
Rattus norvegicus | angiotensin III + L-Asp | - |
? | |
angiotensin II + H2O | - |
Rattus norvegicus Wistar | angiotensin III + L-Asp | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aminopeptidase A | - |
Rattus norvegicus |
AP A | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | influence of thyroid disorders on the kidney expression and plasma activity of aminopeptidase A. In plasma, hyperthyroid rats demonstrate slight but significantly lower levels of AP A than euthyroid (control) rats | Rattus norvegicus |
metabolism | thyroid disorders affect blood pressure and renal function through changes in the components of the local renin-angiotensin system such as aminopeptidase A (AP A or GluAP), which metabolizes angiotensin II (Ang II) to angiotensin III (Ang III), consequently regulating their functions | Rattus norvegicus |