Cloned (Comment) | Organism |
---|---|
gene Enpep, quantitative real-time PCR enzyme expression analysis | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no enzyme inhibition by leptin, but reduction of enzyme level in blood, although not in kidney | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin II + H2O | Mus musculus | - |
angiotensin III + L-Asp | - |
? | |
angiotensin II + H2O | Mus musculus C57BL/6 | - |
angiotensin III + L-Asp | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P16406 | - |
- |
Mus musculus C57BL/6 | P16406 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Mus musculus | - |
heart | low enzyme level | Mus musculus | - |
kidney | high enzyme level | Mus musculus | - |
liver | moderate enzyme level | Mus musculus | - |
lung | moderate enzyme level | Mus musculus | - |
additional information | quantitative real-time PCR enzyme expression analysis | Mus musculus | - |
skeletal muscle | low enzyme level | Mus musculus | - |
white adipose tissue | low enzyme level | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin II + H2O | - |
Mus musculus | angiotensin III + L-Asp | - |
? | |
angiotensin II + H2O | - |
Mus musculus C57BL/6 | angiotensin III + L-Asp | - |
? | |
L-glutamyl beta-naphthylamide + H2O | - |
Mus musculus | L-Glu + beta-naphthylamine | - |
? | |
L-glutamyl beta-naphthylamide + H2O | - |
Mus musculus C57BL/6 | L-Glu + beta-naphthylamine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aminopeptidase A | - |
Mus musculus |
APA | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | long-term leptin treatment reduces APA activity in the blood but not in kidney, but incubation of ob/+ and ob/ob mice with leptin does not change APA activity | down |
General Information | Comment | Organism |
---|---|---|
malfunction | higher APA activity is observed in the kidney and lower activity in lung of ob/ob mice. High aminopeptidase A (APA) activity contributes to blood pressure control in ob/ob mice through an AT2 receptor-dependent mechanism | Mus musculus |
physiological function | aminopeptidase A enzyme metabolizes angiotensin (ANG) II into ANG III, a peptide associated with intrarenal angiotensin type 2 (AT2) receptor activation and induction of natriuresis. Role of AT2 receptor and APA as active mechanisms regulating blood pressure in ob/ob mice, overview | Mus musculus |