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Literature summary for 3.4.11.7 extracted from

  • Tamura, N.; Lottspeich, F.; Baumeister, W.; Tamura, T.
    The role of tricorn protease and its aminopeptidase-interacting factors in cellular protein degradation (1998), Cell, 95, 637-648 .
    View publication on PubMed
Search for more literature for 3.4.11.7

Cloned(Commentary)

Cloned (Comment) Organism
-
 Thermoplasma acidophilum

Organism

Organism UniProt Comment Textmining
Thermoplasma acidophilum O93655
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.6
-
 substrate: L-Arg-7-amido-4-methylcoumarin, pH 8.0, 60°C Thermoplasma acidophilum
0.7
-
 substrate: L-Tyr-7-amido-4-methylcoumarin, pH 8.0, 60°C Thermoplasma acidophilum
0.8
-
 substrate: L-Phe-7-amido-4-methylcoumarin, pH 8.0, 60°C Thermoplasma acidophilum
1
-
 substrate: L-Val-7-amido-4-methylcoumarin, pH 8.0, 60°C Thermoplasma acidophilum
1.1
-
 substrate: Gly-7-amido-4-methylcoumarin, pH 8.0, 60°C Thermoplasma acidophilum
3
-
 substrate: L-Pro-7-amido-4-methylcoumarin, pH 8.0, 60°C Thermoplasma acidophilum
15
-
 substrate: L-Ala-7-amido-4-methylcoumarin, pH 8.0, 60°C Thermoplasma acidophilum
34.7
-
 substrate: L-Leu-7-amido-4-methylcoumarin, pH 8.0, 60°C Thermoplasma acidophilum
72.4
-
 substrate: L-Glu-7-amido-4-methylcoumarin, pH 8.0, 60°C Thermoplasma acidophilum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gly-7-amido-4-methylcoumarin + H2O
-
 Thermoplasma acidophilum Gly + 7-amino-4-methylcoumarin
-
 ?
L-Ala-7-amido-4-methylcoumarin + H2O
-
 Thermoplasma acidophilum L-Ala + 7-amino-4-methylcoumarin
-
 ?
L-Arg-7-amido-4-methylcoumarin + H2O
-
 Thermoplasma acidophilum L-Arg + 7-amino-4-methylcoumarin
-
 ?
L-Glu-7-amido-4-methylcoumarin + H2O
-
 Thermoplasma acidophilum L-Glu + 7-amino-4-methylcoumarin
-
 ?
L-Leu-7-amido-4-methylcoumarin + H2O
-
 Thermoplasma acidophilum L-Leu + 7-amino-4-methylcoumarin
-
 ?
L-Phe-7-amido-4-methylcoumarin + H2O
-
 Thermoplasma acidophilum L-Phe + 7-amino-4-methylcoumarin
-
 ?
L-Pro-7-amido-4-methylcoumarin + H2O
-
 Thermoplasma acidophilum L-Pro + 7-amino-4-methylcoumarin
-
 ?
L-Tyr-7-amido-4-methylcoumarin + H2O
-
 Thermoplasma acidophilum L-Tyr + 7-amino-4-methylcoumarin
-
 ?
L-Val-7-amido-4-methylcoumarin + H2O
-
 Thermoplasma acidophilum L-Val + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
tricorn protease-interacting factor F3
-
 Thermoplasma acidophilum

General Information

General Information Comment Organism
metabolism Tricorn, and its interacting factors, F1, F2, and F3 convert proteins efficiently into amino acids. It is quite likely that Tricorn also acts in vivo downstream of the proteasome and, in cooperation with its interacting factors, completes protein catabolic pathways Thermoplasma acidophilum