Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | Ca2+ up- or down-regulates the enzyme activity depending on the substrate tested | Mus musculus | |
Ca2+ | Ca2+ up- or down-regulates the enzyme activity depending on the substrate tested | Homo sapiens | |
Ca2+ | Ca2+ up- or down-regulates the enzyme activity depending on the substrate tested | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
medicine | aminopeptidases play an important role in the regulation of blood pressure, and in the regulation of other pathophysiological processes such as angiogenesis, antigen-presentation, and fertility most probably by mediating the metabolism of some peptide substrates | Mus musculus |
medicine | aminopeptidases play an important role in the regulation of blood pressure, and in the regulation of other pathophysiological processes such as angiogenesis, antigen-presentation, and fertility most probably by mediating the metabolism of some peptide substrates | Homo sapiens |
medicine | aminopeptidases play an important role in the regulation of blood pressure, and in the regulation of other pathophysiological processes such as angiogenesis, antigen-presentation, and fertility most probably by mediating the metabolism of some peptide substrates | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
angiotensin IV | - |
Homo sapiens | |
angiotensin IV | - |
Mus musculus | |
angiotensin IV | - |
Rattus norvegicus | |
Ca2+ | Ca2+ up- or down-regulates the enzyme activity depending on the substrate tested | Homo sapiens | |
Ca2+ | Ca2+ up- or down-regulates the enzyme activity depending on the substrate tested | Mus musculus | |
Ca2+ | Ca2+ up- or down-regulates the enzyme activity depending on the substrate tested | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
membrane | - |
Homo sapiens | 16020 | - |
membrane | - |
Rattus norvegicus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | - |
Mus musculus | |
Zn2+ | - |
Homo sapiens | |
Zn2+ | - |
Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45000 | - |
only the C-terminal domain of the extracellular domain, obtained by proteolytic fragmentation | Mus musculus |
45000 | - |
only the C-terminal domain of the extracellular domain, obtained by proteolytic fragmentation | Homo sapiens |
45000 | - |
only the C-terminal domain of the extracellular domain, obtained by proteolytic fragmentation | Rattus norvegicus |
107000 | - |
only the catalytic part of the extracellular domain of the membrane-spanning protein | Mus musculus |
107000 | - |
only the catalytic part of the extracellular domain of the membrane-spanning protein | Homo sapiens |
107000 | - |
only the catalytic part of the extracellular domain of the membrane-spanning protein | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Glu-7-amido-4-methylcoumarin + H2O | - |
Mus musculus | Glu + 7-amino-4-methylcoumarin | - |
? | |
Glu-7-amido-4-methylcoumarin + H2O | - |
Rattus norvegicus | Glu + 7-amino-4-methylcoumarin | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | full-length enzyme forms a dimer via a disulfide bond, this bond is not essential for dimer formation or enzymatic activity | Mus musculus |
dimer | full-length enzyme forms a dimer via a disulfide bond, this bond is not essential for dimer formation or enzymatic activity | Homo sapiens |
dimer | full-length enzyme forms a dimer via a disulfide bond, this bond is not essential for dimer formation or enzymatic activity | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
aminopeptidase A | - |
Mus musculus |
aminopeptidase A | - |
Homo sapiens |
aminopeptidase A | - |
Rattus norvegicus |
glutamyl aminopeptidase | - |
Mus musculus |
glutamyl aminopeptidase | - |
Homo sapiens |
glutamyl aminopeptidase | - |
Rattus norvegicus |
hAPA | - |
Homo sapiens |
mAPA | - |
Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
measured with Glu-4-methlcoumaryl-7-amide, Glu-MCA, as a substrate | Mus musculus |
7 | - |
measured with Glu-4-methlcoumaryl-7-amide, Glu-MCA, as a substrate | Homo sapiens |
7 | - |
measured with Glu-4-methlcoumaryl-7-amide, Glu-MCA, as a substrate | Rattus norvegicus |