Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | - |
Rattus norvegicus | |
Cd2+ | complete inhibition at 1 mM | Rattus norvegicus | |
Cu2+ | complete inhibition at 1 mM | Rattus norvegicus | |
EC33 | specific inhibition | Rattus norvegicus | |
EDTA | - |
Rattus norvegicus | |
EGTA | - |
Rattus norvegicus | |
Hg2+ | complete inhibition at 1 mM | Rattus norvegicus | |
Ni2+ | complete inhibition at 1 mM | Rattus norvegicus | |
RB150 | selective and specific prodrug of the enzyme inhibitor EC33, inhibits the enzyme given i.v. to rats | Rattus norvegicus | |
Zn2+ | complete inhibition at 1 mM | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | the enzyme has cytosolic and transmembrane regions | Rattus norvegicus | 5737 | - |
membrane | the enzyme has cytosolic and transmembrane regions | Rattus norvegicus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activates | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45000 | 400000 | dependent on the tissue source and purification method | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
enterocyte | intestinal, brush border | Rattus norvegicus | - |
hypothalamus | - |
Rattus norvegicus | - |
kidney | brush border | Rattus norvegicus | - |
additional information | broad tissue distribution | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme catalyzes the hydrolysis of N-(alpha-L-glutamyl)- moieties more efficiently than the hydrolysis of alpha-L-aspartyl derivatives | Rattus norvegicus | ? | - |
? | |
N-(alpha-L-glutamyl)-4-nitroanilide + H2O | - |
Rattus norvegicus | L-glutamic acid + 4-nitroaniline | - |
? | |
N-(alpha-L-glutamyl)-beta-naphthylamide + H2O | - |
Rattus norvegicus | L-glutamic acid + beta-naphthylamine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acidic alpha-aminopeptidase | - |
Rattus norvegicus |
aminopeptidase A | - |
Rattus norvegicus |
angiotensinase A | - |
Rattus norvegicus |
APA | - |
Rattus norvegicus |
aspartate aminopeptidase | - |
Rattus norvegicus |
Ca2+-activated glutamate aminopeptidase | - |
Rattus norvegicus |
EAP | - |
Rattus norvegicus |
glutamyl aminopeptidase | - |
Rattus norvegicus |
membrane aminopeptidase II | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
approximately | Rattus norvegicus |