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Literature summary for 3.4.11.7 extracted from

  • Iturrioz, X.; Reaux-Le Goazigo, A.; Llorens-Cortes, C.
    Aminopeptidase inhibitors as anti-hypertensive drugs (2004), Aminopetidases in Biology and Disease (Hooper, N. M. ; Lendaechel, U. , eds. ) Springer, 2, 229-250.
No PubMed abstract available

Application

Application Comment Organism
drug development the enzyme is a target for design of specific inhibitors Mus musculus
drug development the enzyme is a target for design of specific inhibitors Homo sapiens
drug development the enzyme is a target for design of specific inhibitors Rattus norvegicus
drug development the enzyme is a target for design of specific inhibitors Sus scrofa

Cloned(Commentary)

Cloned (Comment) Organism
gene APA, DNA and amino acid sequence determination and analysis Homo sapiens
gene APA, DNA and amino acid sequence determination and analysis Rattus norvegicus
gene APA, DNA and amino acid sequence determination and analysis Sus scrofa
gene APA, DNA and amino acid sequence determination and analysis, genetic organization and structure Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of active site residue mutants Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
amastatin inhibits the enzyme and blocks the metabolism of brain angiotensin II and III Homo sapiens
amastatin inhibits the enzyme and blocks the metabolism of brain angiotensin II and III Mus musculus
amastatin inhibits the enzyme and blocks the metabolism of brain angiotensin II and III Rattus norvegicus
amastatin inhibits the enzyme and blocks the metabolism of brain angiotensin II and III Sus scrofa
bestatin inhibits the enzyme and blocks the metabolism of brain angiotensin II and III Homo sapiens
bestatin inhibits the enzyme and blocks the metabolism of brain angiotensin II and III Mus musculus
bestatin inhibits the enzyme and blocks the metabolism of brain angiotensin II and III Rattus norvegicus
bestatin inhibits the enzyme and blocks the metabolism of brain angiotensin II and III Sus scrofa
Ca2+ substrate-specific inhibition, overview Homo sapiens
Ca2+ substrate-specific inhibition, overview Mus musculus
Ca2+ substrate-specific inhibition, overview Rattus norvegicus
Ca2+ substrate-specific inhibition, overview Sus scrofa
Cd2+
-
Homo sapiens
Cd2+
-
Mus musculus
Cd2+
-
Rattus norvegicus
Cd2+
-
Sus scrofa
Cu2+
-
Homo sapiens
Cu2+
-
Mus musculus
Cu2+
-
Rattus norvegicus
Cu2+
-
Sus scrofa
EC33 highly selective APA inhibitor Homo sapiens
EC33 highly selective APA inhibitor Mus musculus
EC33 highly selective APA inhibitor Rattus norvegicus
EC33 highly selective APA inhibitor Sus scrofa
Hg2+
-
Homo sapiens
Hg2+
-
Mus musculus
Hg2+
-
Rattus norvegicus
Hg2+
-
Sus scrofa
Ni2+
-
Homo sapiens
Ni2+
-
Mus musculus
Ni2+
-
Rattus norvegicus
Ni2+
-
Sus scrofa
Zn2+
-
Homo sapiens
Zn2+
-
Mus musculus
Zn2+
-
Rattus norvegicus
Zn2+
-
Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane bound, type II integral membrane protein, the enzyme contains an ectodomain Mus musculus 16020
-
membrane bound, type II integral membrane protein, the enzyme contains an ectodomain Homo sapiens 16020
-
membrane bound, type II integral membrane protein, the enzyme contains an ectodomain Rattus norvegicus 16020
-
membrane bound, type II integral membrane protein, the enzyme contains an ectodomain Sus scrofa 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates, best at 1 mM, substrate-specific activation Mus musculus
Ca2+ activates, best at 1 mM, substrate-specific activation Homo sapiens
Ca2+ activates, best at 1 mM, substrate-specific activation Rattus norvegicus
Ca2+ activates, best at 1 mM, substrate-specific activation Sus scrofa
Zn2+ zinc-metallopeptidase, the enzyme contains the zinc-binding motif HEXXH Homo sapiens
Zn2+ zinc-metallopeptidase, the enzyme contains the zinc-binding motif HEXXH Rattus norvegicus
Zn2+ zinc-metallopeptidase, the enzyme contains the zinc-binding motif HEXXH Sus scrofa
Zn2+ zinc-metallopeptidase, the enzyme contains the zinc-binding motif HEXXH residues 385-389 with catalytically important Glu386 Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
250000 300000
-
Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin III + H2O Mus musculus the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension angiotensin IV + Arg
-
ir
angiotensin III + H2O Homo sapiens the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension angiotensin IV + Arg
-
ir
angiotensin III + H2O Rattus norvegicus the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension angiotensin IV + Arg
-
ir
angiotensin III + H2O Sus scrofa the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension angiotensin IV + Arg
-
ir
additional information Mus musculus the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview ?
-
?
additional information Homo sapiens the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview ?
-
?
additional information Rattus norvegicus the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview ?
-
?
additional information Sus scrofa the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-
Rattus norvegicus
-
WKY rats
-
Sus scrofa
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein N-linked glycans Mus musculus
glycoprotein N-linked glycans Homo sapiens
glycoprotein N-linked glycans Rattus norvegicus
glycoprotein N-linked glycans Sus scrofa

Reaction

Reaction Comment Organism Reaction ID
release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide active site structure and organization Homo sapiens
release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide active site structure and organization Rattus norvegicus
release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide active site structure and organization Sus scrofa
release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide active site structure and organization, modeling, residues Glu352, Glu386, Tyr471, and Glu408 are important in catalysis Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Homo sapiens
-
B-lymphocyte immature B-lineage cell Mus musculus
-
B-lymphocyte immature B-lineage cell Homo sapiens
-
B-lymphocyte immature B-lineage cell Rattus norvegicus
-
B-lymphocyte immature B-lineage cell Sus scrofa
-
bile duct
-
Homo sapiens
-
bone marrow
-
Mus musculus
-
bone marrow
-
Homo sapiens
-
bone marrow
-
Rattus norvegicus
-
bone marrow
-
Sus scrofa
-
brain pericyte Mus musculus
-
brain pericyte Homo sapiens
-
brain pericyte Rattus norvegicus
-
brain pericyte Sus scrofa
-
brain pericyte and almost all structures, hyperactive in RAS and SHR, distribution overview Rattus norvegicus
-
epididymis basement membrane Homo sapiens
-
epithelium
-
Homo sapiens
-
gall bladder epithelium
-
Homo sapiens
-
heart
-
Homo sapiens
-
hepatocyte
-
Homo sapiens
-
liver bile canaliculi Homo sapiens
-
lung
-
Homo sapiens
-
ovary theca interna Homo sapiens
-
pancreas interlobular ducts Homo sapiens
-
pericyte brain Mus musculus
-
pericyte brain Homo sapiens
-
pericyte brain Rattus norvegicus
-
pericyte brain Sus scrofa
-
placenta syncytiotrophoblast cells Homo sapiens
-
syncytiotrophoblast
-
Homo sapiens
-
thymus stromal cells of the cortex Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O cleavage only in vitro Mus musculus ?
-
?
angiotensin I + H2O cleavage only in vitro Homo sapiens ?
-
?
angiotensin I + H2O cleavage only in vitro Rattus norvegicus ?
-
?
angiotensin I + H2O cleavage only in vitro Sus scrofa ?
-
?
angiotensin II + H2O i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Mus musculus Asp + angiotensin III i.e. Arg-Val-Tyr-Ile-His-Pro-Phe ir
angiotensin II + H2O i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Homo sapiens Asp + angiotensin III i.e. Arg-Val-Tyr-Ile-His-Pro-Phe ir
angiotensin II + H2O i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Rattus norvegicus Asp + angiotensin III i.e. Arg-Val-Tyr-Ile-His-Pro-Phe ir
angiotensin II + H2O i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Sus scrofa Asp + angiotensin III i.e. Arg-Val-Tyr-Ile-His-Pro-Phe ir
angiotensin III + H2O the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension Mus musculus angiotensin IV + Arg
-
ir
angiotensin III + H2O the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension Homo sapiens angiotensin IV + Arg
-
ir
angiotensin III + H2O the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension Rattus norvegicus angiotensin IV + Arg
-
ir
angiotensin III + H2O the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension Sus scrofa angiotensin IV + Arg
-
ir
cholecystokinin-8 + H2O cleavage only in vitro Mus musculus ?
-
?
cholecystokinin-8 + H2O cleavage only in vitro Homo sapiens ?
-
?
cholecystokinin-8 + H2O cleavage only in vitro Rattus norvegicus ?
-
?
cholecystokinin-8 + H2O cleavage only in vitro Sus scrofa ?
-
?
additional information the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview Mus musculus ?
-
?
additional information the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview Homo sapiens ?
-
?
additional information the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview Rattus norvegicus ?
-
?
additional information the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview Sus scrofa ?
-
?
additional information substrate specificity, overview, the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides Mus musculus ?
-
?
additional information substrate specificity, overview, the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides Homo sapiens ?
-
?
additional information substrate specificity, overview, the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides Rattus norvegicus ?
-
?
additional information substrate specificity, overview, the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides Sus scrofa ?
-
?
N-(alpha-L-Ala-L-Leu-L-Lys-Arg)-2-naphthylamide + H2O
-
Mus musculus ?
-
?
N-(alpha-L-Ala-L-Leu-L-Lys-Arg)-2-naphthylamide + H2O
-
Homo sapiens ?
-
?
N-(alpha-L-Ala-L-Leu-L-Lys-Arg)-2-naphthylamide + H2O
-
Rattus norvegicus ?
-
?
N-(alpha-L-Ala-L-Leu-L-Lys-Arg)-2-naphthylamide + H2O
-
Sus scrofa ?
-
?
N-(alpha-L-aspartylyl)-2-naphthylamide + H2O
-
Mus musculus L-aspartic acid + 2-naphthylamine
-
?
N-(alpha-L-aspartylyl)-2-naphthylamide + H2O
-
Homo sapiens L-aspartic acid + 2-naphthylamine
-
?
N-(alpha-L-aspartylyl)-2-naphthylamide + H2O
-
Rattus norvegicus L-aspartic acid + 2-naphthylamine
-
?
N-(alpha-L-aspartylyl)-2-naphthylamide + H2O
-
Sus scrofa L-aspartic acid + 2-naphthylamine
-
?
N-(alpha-L-glutamyl)-2-naphthylamide + H2O
-
Mus musculus L-glutamic acid + 2-naphthylamine
-
?
N-(alpha-L-glutamyl)-2-naphthylamide + H2O
-
Homo sapiens L-glutamic acid + 2-naphthylamine
-
?
N-(alpha-L-glutamyl)-2-naphthylamide + H2O
-
Rattus norvegicus L-glutamic acid + 2-naphthylamine
-
?
N-(alpha-L-glutamyl)-2-naphthylamide + H2O
-
Sus scrofa L-glutamic acid + 2-naphthylamine
-
?

Subunits

Subunits Comment Organism
dimer 2 * 120000-185000, SDS-PAGE Mus musculus
dimer 2 * 120000-185000, SDS-PAGE Homo sapiens
dimer 2 * 120000-185000, SDS-PAGE Sus scrofa
dimer three-dimensional structure determination and analysis, modeling Rattus norvegicus
monomer three-dimensional structure determination and analysis, modeling Rattus norvegicus
More three-dimensional structure determination and analysis, modeling Homo sapiens
More three-dimensional structure determination and analysis, modeling Sus scrofa
More three-dimensional structure determination and analysis, modeling, the enzyme contains a short N-terminal cytoplasmic domain of 17 amino acid residues, a transmembrane domain of 22 amino acid residues, and a large extracellular domain of 906 amino acid residues in cluding the active and the zinc-binding site Mus musculus

Synonyms

Synonyms Comment Organism
aminopeptidase A
-
Mus musculus
aminopeptidase A
-
Homo sapiens
aminopeptidase A
-
Rattus norvegicus
aminopeptidase A
-
Sus scrofa
APA
-
Mus musculus
APA
-
Homo sapiens
APA
-
Rattus norvegicus
APA
-
Sus scrofa
BP1/6C3
-
Mus musculus
BP1/6C3
-
Homo sapiens
BP1/6C3
-
Rattus norvegicus
BP1/6C3
-
Sus scrofa
More the enzyme belongs to the zinc-metallopeptidase family of zincins Mus musculus
More the enzyme belongs to the zinc-metallopeptidase family of zincins Homo sapiens
More the enzyme belongs to the zinc-metallopeptidase family of zincins Rattus norvegicus
More the enzyme belongs to the zinc-metallopeptidase family of zincins Sus scrofa