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Literature summary for 3.4.11.7 extracted from

  • Danielsen, E.M.; Noren, O.; Sjoestroem, H.; Ingram, J.; Kenny, A.J.
    Proteins of the kidney microvillar membrane. Aspartate aminopeptidase: purification by immunoadsorbent chromatography and properties of the detergent- and proteinase-solubilized forms (1980), Biochem. J., 189, 591-603.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.11.7

Inhibitors

Inhibitors Comment Organism Structure
Cu2+
-
 Sus scrofa
dithiothreitol
-
 Sus scrofa
EDTA
-
 Sus scrofa
EGTA
-
 Sus scrofa
mercaptoethanol
-
 Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
microvillus
-
 Sus scrofa 5902
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ba2+ activation Sus scrofa
Ca2+ activation Sus scrofa
Ca2+ tightly bound, 1 mol per 143000 g enzyme Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
270000
-
 proteinase form, gel filtration Sus scrofa
350000 400000 detergent form, gel filtration Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
36.1
-
-
 Sus scrofa

Storage Stability

Storage Stability Organism
-20°C, several months Sus scrofa
4°C, slow inactivation Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Asp-beta-naphthylamide + H2O
-
 Sus scrofa Asp + naphthylamine
-
 ?
Glu-beta-naphthylamide + H2O
-
 Sus scrofa Glu + naphthylamine
-
 ?
L-Asp-peptide + H2O specificity for di- and tri-peptides with Asp or Glu at N-terminal end Sus scrofa L-Asp + peptide
-
 ?
L-Glu-peptide + H2O specificity for di-and tripeptides with Asp or Glu at N-terminal end Sus scrofa L-Glu + peptide
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * ?, electron microscopy after negative staining Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 7
-
 Sus scrofa

pH Range

pH Minimum pH Maximum Comment Organism
4.5 8.5
-
 Sus scrofa