Literature summary for 3.4.11.22 extracted from

Aoki, K.; Furuya, A.; Matsumoto, K.; Tsujimoto, M.
The gene expression of two endoplasmic reticulum aminopeptidase 1 isoforms is regulated by distinct posttranscriptional mechanisms (2018), Biochem. Biophys. Res. Commun., 503, 3180-3185 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NZ08	ERAP1 protein has two isoforms produced by alternative splicing of the 3' terminal exon	-

Synonyms

Synonyms	Comment	Organism
ERAP1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	ERAP1 protein has two isoforms produced by alternative splicing of the 3' terminal exon. The isoforms undergo different posttranscriptional regulation mechanisms via their respective 3' untranslated regions. The 19E isoform, having exon 19 as last exon, undergoes suppressive translational control and is specifically induced by IFN-gamma stimulation. The 20E isoform has exon 20 as last exon and might act as a housekeeping gene	Homo sapiens

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Release 2023.1 (January 2023)