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Literature summary for 3.4.11.22 extracted from
- Endoplasmic reticulum aminopeptidase-1 functions regulate key aspects of the innate immune response (2013), PLoS ONE, 8, e69539.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q9EQH2 | - |
- |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | mice lacking isoform ERAP1 exhibit exaggerated innate immune responses early during pathogen recognition, as characterized by increased activation of splenic and hepatic natural killer and natural killer T-cells and enhanced production of proinflammatory cytokines such as IL12 and MCP1. ERAP1 is playing a critical role in natural killer cell development and function. ERAP1-KO mice show higher frequencies of terminally matured natural killer cells, as well as higher frequencies of licensed natural killer cells expressing the Ly49C and Ly49I receptors which positively correlates with an enhanced natural killer cell activation and IFNc production by ERAP1-KO mice challenged with pro-inflammatory stimuli. During pathogen recognition, ERAP1 regulates IL12 production by CD11c+ dendritic cells specifically | Mus musculus |
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Release 2023.1 (January 2023)
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