Application | Comment | Organism |
---|---|---|
medicine | in both HeLa-B27 and C1R-B27 cells, the proportion of 9-mer HLA-B27-bound peptides is decreased by isoform ERAP1 silencing, whereas the percentages of longer peptides, 11-13 mer, are increased. Following ERAP1 silencing, C-terminally extended peptides are readily identified. These are better able to bind to HLAB27 than N-terminally extended peptides lacking an arginine at position 2. In both HeLa-B27 cells and mouse fibroblasts expressing HLA-B27, the absence of ERAP1 reduces peptide recognition by HLA-B27-restricted immunodominant viral HLAB27 epitope KK10-specific cytotoxic T-lymphocytes. Presence of an ankylosing spondylitis-protective variant of ERAP1, K528R, as compared to wild-type ERAP1, reduces the peptide recognition by KK10 cytotoxic T lymphocytes following transfection with extended KK10 minigenes | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NZ08 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C1R-B27 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
endoplasmic reticulum aminopeptidase 1 | - |
Homo sapiens |
ERAP1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | in both HeLa-B27 and C1R-B27 cells, the proportion of 9-mer HLA-B27-bound peptides is decreased by isoform ERAP1 silencing, whereas the percentages of longer peptides, 11-13 mer, are increased. Following ERAP1 silencing, C-terminally extended peptides are readily identified. These are better able to bind to HLAB27 than N-terminally extended peptides lacking an arginine at position 2. In both HeLa-B27 cells and mouse fibroblasts expressing HLA-B27, the absence of ERAP1 reduces peptide recognition by HLA-B27-restricted immunodominant viral HLAB27 epitope KK10-specific cytotoxic T-lymphocytes. Presence of an ankylosing spondylitis-protective variant of ERAP1, K528R, as compared to wild-type ERAP1, reduces the peptide recognition by KK10 cytotoxic T lymphocytes following transfection with extended KK10 minigenes | Homo sapiens |