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Literature summary for 3.4.11.22 extracted from
- Secretion of endoplasmic reticulum aminopeptidase 1 is involved in the activation of macrophages induced by lipopolysaccharide and interferon-gamma (2011), J. Biol. Chem., 286, 21906-21914.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Sf9 insect cells | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| E354Q | inactive, Zn2+ binding site disrupted | Mus musculus |
| Q181E | different substrate specificity, cleaves basic amino acid residues preferentially | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| amastatin | - |
Mus musculus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Mus musculus | 5783 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 105000 | - |
x * 105000, also a 114000 form of the glycoprotein, SDS-PAGE, | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Mus musculus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| from culture medium, hydroxyapatite chromatography, immobilized metal ion affinity chromatography (Co2+) | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| RAW-264.7 cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-leucine-4-methylcoumaryl-7-amide + H2O | - |
Mus musculus | L-leucine + 7-amino-4-methylcoumarin | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 105000, also a 114000 form of the glycoprotein, SDS-PAGE, | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| endoplasmic reticulum aminopeptidase 1 | - |
Mus musculus |
| ERAP1 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | secreted from RAW-264.7 cells after costimulation with lipopolysaccharide and interferon-gamma | Mus musculus |
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Release 2023.1 (January 2023)
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