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Literature summary for 3.4.11.22 extracted from

  • Hammer, G.E.; Gonzalez, F.; Champsaur, M.; Cado, D.; Shastri, N.
    The aminopeptidase ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules (2006), Nat. Immunol., 7, 103-112.
    View publication on PubMed
Search for more literature for 3.4.11.22

Protein Variants

Protein Variants Comment Organism
additional information generation of ERAAP-deficient mutant mice of strain 129/J by gene excision, the mutants show reduced and altered MHC class I molecules Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Mus musculus 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules, overview, loss of enzyme results in disruption of generation of naturally processed peptides in the endoplasmic reticulum, decreased stability of peptide-MHC class I complexes, and diminished CD8+ T cell responses ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules, overview, loss of enzyme results in disruption of generation of naturally processed peptides in the endoplasmic reticulum, decreased stability of peptide-MHC class I complexes, and diminished CD8+ T cell responses Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
ER aminopeptidase associated with antigen processing
-
 Mus musculus
ERAAP
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 Mus musculus