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Literature summary for 3.4.11.2 extracted from

  • Wulfaenger, J.; Niedling, S.; Riemann, D.; Seliger, B.
    Aminopeptidase N (APN)/CD13-dependent CXCR4 downregulation is associated with diminished cell migration, proliferation and invasion (2008), Mol. Membr. Biol., 25, 72-82.
    View publication on PubMed
Search for more literature for 3.4.11.2

Cloned(Commentary)

Cloned (Comment) Organism
expression in human embryonic kidney cell Homo sapiens

Protein Variants

Protein Variants Comment Organism
E354G almost complete loss of activity Homo sapiens
E354I almost complete loss of activity Homo sapiens
E354Q almost complete loss of activity Homo sapiens
E388G almost complete loss of activity Homo sapiens
E410G almost complete loss of activity Homo sapiens
H387C/H391C almost complete loss of activity Homo sapiens
H387I/H391I almost complete loss of activity Homo sapiens
additional information expression of wild-type enzyme in human embryonic kidney cells is associated with significant decrease in proliferation, migration and also reduced anchorage-independent growth. Effects are due to downregulated mRNA and protein expression of chemokine receptor CXCR4 and an inhibition of the stromal cell-derived factor (SDF)-1alpha/CXCL12-mediated migration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
U-937 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ala-4-nitroanilide + H2O
-
 Homo sapiens L-Ala + 4-nitroaniline
-
 ?