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Literature summary for 3.4.11.2 extracted from

  • Gera, L.; Fortin, J.; Adam, A.; Stewart, J.M.; Marceau, F.
    Discovery of a dual-function peptide that combines aminopeptidase N inhibition and kinin B1 receptor antagonism (2006), J. Pharmacol. Exp. Ther., 317, 300-308.
    View publication on PubMed
Search for more literature for 3.4.11.2

Inhibitors

Inhibitors Comment Organism Structure
amastatin
-
 Homo sapiens
amastatin
-
 Oryctolagus cuniculus
D-Arg-L-Lys-[Hyp3, CpG5, D-Tic7, CpG8]des-Arg9-bradykinin competitive to L-Ala-4-nitroanilide, additionally inhibitory to kinin B1 receptor Homo sapiens
D-Arg-L-Lys-[Hyp3, CpG5, D-Tic7, CpG8]des-Arg9-bradykinin competitive to L-Ala-4-nitroanilide, additionally inhibitory to kinin B1 receptor Oryctolagus cuniculus
L-Lys-L-Lys-[Hyp3, CpG5, D-Tic7, CpG8]des-Arg9-bradykinin competitive to L-Ala-4-nitroanilide Homo sapiens
L-Lys-L-Lys-[Hyp3, CpG5, D-Tic7, CpG8]des-Arg9-bradykinin competitive to L-Ala-4-nitroanilide Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-
membrane
-
 Oryctolagus cuniculus 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
artery arterial smooth muscle Homo sapiens
-
artery arterial smooth muscle Oryctolagus cuniculus
-
smooth muscle arterial smooth muscle Homo sapiens
-
smooth muscle arterial smooth muscle Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ala-4-nitroanilide + H2O
-
 Homo sapiens L-Ala + 4-nitroaniline
-
 ?
L-Ala-4-nitroanilide + H2O
-
 Oryctolagus cuniculus L-Ala + 4-nitroaniline
-
 ?
L-Lys-L-Lys-[Hyp3, CpG5, D-Tic7, CpG8]des-Arg9-bradykinin + H2O i.e.B-9958 Homo sapiens ?
-
 ?
L-Lys-L-Lys-[Hyp3, CpG5, D-Tic7, CpG8]des-Arg9-bradykinin + H2O i.e.B-9958 Oryctolagus cuniculus ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00086
-
 D-Arg-L-Lys-[Hyp3, CpG5, D-Tic7, CpG8]des-Arg9-bradykinin
-
 Oryctolagus cuniculus
0.00096
-
 L-Lys-L-Lys-[Hyp3, CpG5, D-Tic7, CpG8]des-Arg9-bradykinin
-
 Oryctolagus cuniculus
0.0022
-
 D-Arg-L-Lys-[Hyp3, CpG5, D-Tic7, CpG8]des-Arg9-bradykinin
-
 Homo sapiens
0.00487
-
 L-Lys-L-Lys-[Hyp3, CpG5, D-Tic7, CpG8]des-Arg9-bradykinin
-
 Homo sapiens