Literature summary for 3.4.11.2 extracted from

Thielitz, A.; Reinhold, D.; Vetter, R.; Bank, U.; Helmuth, M.; Hartig, R.; Wrenger, S.; Wiswedel, I.; Lendeckel, U.; Kaehne, T.; Neubert, K.; Faust, J.; Zouboulis, C.C.; Ansorge, S.; Gollnick, H.
Inhibitors of dipeptidyl peptidase IV and aminopeptidase N target major pathogenetic steps in acne initiation (2007), J. Invest. Dermatol., 127, 1042-1051.

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Application

Application	Comment	Organism
medicine	aminopeptidase N and dipeptidyl peptidase IV have a functional role in sebaceous gland and their inhibition may affect Acne vulgaris pathogenesis	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
actinonin	inhibition results in supppressed proliferation, enhanced terminal differentiation, and slightly decreased total neutral lipid production in sebocytes. In presence of inhibitor, cytokine IL-1 receptor antagonist is significantly upregulated and inhibitor suppresses proliferation and cytokine IL-2 production in Propionibacterium acnes-stimulated T-cells	Homo sapiens
bestatin	inhibition results in supppressed proliferation, enhanced terminal differentiation, and slightly decreased total neutral lipid production in sebocytes. In presence of inhibitor, cytokine IL-1 receptor antagonist is significantly upregulated and inhibitor suppresses proliferation and cytokine IL-2 production in Propionibacterium acnes-stimulated T-cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
sebocyte	-	Homo sapiens	-
SZ-95 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)