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Literature summary for 3.4.11.2 extracted from

  • Bank, U.; Tadje, J.; Taeger, M.; Wolke, C.; Bukowska, A.; Ittenson, A.; Reinhold, D.; Helmuth, M.; Ansorge, S.; Shakespeare, A.; Vieth, M.; Malfertheiner, P.; Naumann, M.; Lendeckel, U.
    Inhibition of alanyl-aminopeptidase on CD4+CD25+ regulatory T-cells enhances expression of FoxP3 and TGF-beta1 and ameliorates acute colitis in mice (2007), Int. J. Mol. Med., 20, 483-492.
    View publication on PubMed

Application

Application Comment Organism
medicine pre-treatment of CD24+Cd25+ T-cells with aminopeptidase N inhibitor phebestin substantially enhances the suppressive activity of these cells and increases expression levels of transforming growth factor TGF-beta1 and FoxP3 and ameliorates acute colitis Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
phebestin
-
Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
splenocyte
-
Mus musculus
-
T-cell CD24+Cd25+ T-cell Mus musculus
-