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Literature summary for 3.4.11.2 extracted from

  • Wentworth, D.E.; Tresnan, D.B.; Turner, B.C.; Lerman, I.R.; Bullis, B.; Hemmila, E.M.; Levis, R.; Shapiro, L.H.; Holmes, K.V.
    Cells of human aminopeptidase N (CD13) transgenic mice are infected by human coronavirus-229E in vitro, but not in vivo (2005), Virology, 335, 185-197.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of the enzyme in murine CMT93 cells and in transgenic mice Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of transgenic mice expressing the enzyme in kidney, small intestine, liver, and lung on epithelial cell surface, transfection with the human coronavirus-229E is possible only in vitro in murine embryonic and bone marrow dendritic cells, not in vivo in transgenic mice via intranasal, intracranial, or intragastric inoculation, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
Homo sapiens 9986
-
plasma membrane ectoenzyme Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the ectoenzyme acts as a receptor for human coronavirus 229E, in vivo infection of primary embryonic cells and bone marrow dendritic cells ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P15144
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
Homo sapiens
-
epithelium
-
Homo sapiens
-
fibroblast lung Homo sapiens
-
lung fibroblast Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the ectoenzyme acts as a receptor for human coronavirus 229E, in vivo infection of primary embryonic cells and bone marrow dendritic cells Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
aminopeptidase N
-
Homo sapiens
APN
-
Homo sapiens
CD13
-
Homo sapiens