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Literature summary for 3.4.11.2 extracted from
- Expression of CD13/aminopeptidase N and CD10/neutral endopeptidase on cultured human keratinocytes (2004), Immunol. Lett., 91, 39-47.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| actinonin | competitive, moderate inhibition of keratinocyte growth | Homo sapiens |  |
| anti-CD13 antibody WM15 | enzyme blocking, commercial preparation | Homo sapiens | |
| bestatin | competitive, low inhibition of keratinocyte growth | Homo sapiens | |
| Substance P | competitive, high inhibition of keratinocyte growth | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | - |
Homo sapiens | 9986 | - |
| membrane | bound | Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the inhibition of APN results in decreased growth of cultured keratinocytes | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | nonstimulated from healthy skin, expression analysis, 100% expression of CD13, high density expression on the cell surface | Homo sapiens | - |
| keratinocyte | nonstimulated from healthy skin, expression analysis, 30% of keratinocytes express CD13, lower density expression on the cell surface | Homo sapiens | - |
| skin | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-Ala-2-naphthylamide + H2O | - |
Homo sapiens | L-Ala + 2-naphthylamine | - |
? | |
| additional information | the inhibition of APN results in decreased growth of cultured keratinocytes | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aminopeptidase N | - |
Homo sapiens |
| APN | - |
Homo sapiens |
| CD13 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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