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Literature summary for 3.4.11.2 extracted from
- Yeast aminopeptidases Ape2, Aap1' and Yin7 (2004), Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds), 1, 316-318.
No PubMed abstract available
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene AAP1', DNA and amino acid sequence determination and analysis, genetic structure, overview | Saccharomyces cerevisiae |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | enzyme overexpression leads to increased enzyme activity, glycogen accumulation, and upregulation of the HSP70 gene SSA3, gene disruption reduces the glycogen accumulation ability | Saccharomyces cerevisiae |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | required for activity, best at 0.05 mM | Saccharomyces cerevisiae |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 97634 | - |
x * 97634, sequence calculation | Saccharomyces cerevisiae |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
gene AAP1' | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | the enzyme possesses 4 potential N-glycosylation sites | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-Ala-2-naphthylamide + H2O | preferred substrate | Saccharomyces cerevisiae | L-Ala + 2-naphthylamine | - |
? | |
| L-Arg-2-naphthylamide + H2O | - |
Saccharomyces cerevisiae | L-Arg + 2-naphthylamine | - |
? | |
| additional information | no activity with N-terminal Leu-substrates | Saccharomyces cerevisiae | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 97634, sequence calculation | Saccharomyces cerevisiae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Aap 1' aminopeptidase | - |
Saccharomyces cerevisiae |
| Aap1 aminopeptidase | - |
Saccharomyces cerevisiae |
| Aap1' | - |
Saccharomyces cerevisiae |
| alanine/arginine aminopeptidase | - |
Saccharomyces cerevisiae |
| More | the enzyme belongs to the M1 peptidase family | Saccharomyces cerevisiae |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Saccharomyces cerevisiae |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Saccharomyces cerevisiae | sequence calculation | - |
5.1 |
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Release 2023.1 (January 2023)
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