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Literature summary for 3.4.11.2 extracted from
- Aminopeptidase N during the ontogeny of the chick (2006), Differentiation, 74, 119-128.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Gallus gallus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| RB129 | - |
Gallus gallus |  |
| RB3014 | APN inhibitor, IC50: 30 nM | Gallus gallus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | bound | Gallus gallus | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | metallopeptidase | Gallus gallus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Gallus gallus | the enzyme is involved in embryonic angiogenesis and development promoting vascular growth and endothelial cell proliferation | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood vessel | angiogenic | Gallus gallus | - |
| brain | - |
Gallus gallus | - |
| egg | fertilized | Gallus gallus | - |
| embryo | occurs with beginning of gastrulation, cardiovascular compartment and hematopoietic compartment, i.e. yolk sac and aorta-gonad-mesonephros region | Gallus gallus | - |
| endoderm | area pelludica, area opaca | Gallus gallus | - |
| epithelium | - |
Gallus gallus | - |
| heart | expression only in the early developmental stages | Gallus gallus | - |
| mesoderm | somtes, extra- and intraembryonic lateral, and blood islands | Gallus gallus | - |
| additional information | enzyme expression and activity during ontogeny, detailed overview, no activity in ectoderm | Gallus gallus | - |
| yolk sac | - |
Gallus gallus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-Ala-2-naphthylamide + H2O | - |
Gallus gallus | L-Ala + 2-naphthylamine | - |
? | |
| additional information | the enzyme is involved in embryonic angiogenesis and development promoting vascular growth and endothelial cell proliferation | Gallus gallus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aminopeptidase N | - |
Gallus gallus |
| APN | - |
Gallus gallus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Gallus gallus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Gallus gallus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00003 | - |
APN inhibitor, IC50: 30 nM | Gallus gallus | RB3014 | |
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Release 2023.1 (January 2023)
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