Inhibitors | Comment | Organism | Structure |
---|---|---|---|
TNP-470 | treatment inhibits programmed cell death in miltefosine-treated promastigotes. It inhibits the biochemical features of metazoan apoptosis, including caspase3/7 protease like activity, oligonucleosomal DNA fragmentation, collapse of mitochondrial transmembrane potential, and increase in cytosolic pool of calcium ions but does not prevent the cell death and phosphatidyl serine externalization | Leishmania donovani |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania donovani | E9BF82 | - |
- |
Leishmania donovani BPK282A1 | E9BF82 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-methionine 4-methylcoumaryl-7-amide + H2O | - |
Leishmania donovani | L-methionine + 7-amino-4-methylcoumarin | - |
? | |
L-methionine 4-methylcoumaryl-7-amide + H2O | - |
Leishmania donovani BPK282A1 | L-methionine + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LdBPK_210960 | - |
Leishmania donovani |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000135 | - |
TNP-470 | pH 7.5, 37°C | Leishmania donovani |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.015 | - |
pH 7.5, 37°C | Leishmania donovani | TNP-470 |
General Information | Comment | Organism |
---|---|---|
physiological function | MAP2 is involved in the regulation of programmed cell death in the parasite | Leishmania donovani |