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Literature summary for 3.4.11.18 extracted from

  • Kumar, R.; Tiwari, K.; Dubey, V.K.
    Methionine aminopeptidase 2 is a key regulator of apoptotic like cell death in Leishmania donovani (2017), Sci. Rep., 7, 95 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
TNP-470 treatment inhibits programmed cell death in miltefosine-treated promastigotes. It inhibits the biochemical features of metazoan apoptosis, including caspase3/7 protease like activity, oligonucleosomal DNA fragmentation, collapse of mitochondrial transmembrane potential, and increase in cytosolic pool of calcium ions but does not prevent the cell death and phosphatidyl serine externalization Leishmania donovani

Organism

Organism UniProt Comment Textmining
Leishmania donovani E9BF82
-
-
Leishmania donovani BPK282A1 E9BF82
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-methionine 4-methylcoumaryl-7-amide + H2O
-
Leishmania donovani L-methionine + 7-amino-4-methylcoumarin
-
?
L-methionine 4-methylcoumaryl-7-amide + H2O
-
Leishmania donovani BPK282A1 L-methionine + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
LdBPK_210960
-
Leishmania donovani

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000135
-
TNP-470 pH 7.5, 37°C Leishmania donovani

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.015
-
pH 7.5, 37°C Leishmania donovani TNP-470

General Information

General Information Comment Organism
physiological function MAP2 is involved in the regulation of programmed cell death in the parasite Leishmania donovani