Literature summary for 3.4.11.18 extracted from

Van Damme, P.; Hole, K.; Gevaert, K.; Arnesen, T.
N-terminal acetylome analysis reveals the specificity of Naa50 (Nat5) and suggests a kinetic competition between N-terminal acetyltransferases and methionine aminopeptidases (2015), Proteomics, 15, 2436-2446 .

Search for more literature for 3.4.11.18

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P50579	isoform MetAP2	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
MAPLDLDRWGRPVGRRRRPVRVYP-OH + H2O	sequence corresponds to the N-terminus of the human serine/threonine-protein phosphatase 6 catalytic subunit protein	Homo sapiens	L-methionine + APLDLDRWGRPVGRRRRPVRVYP-OH	-	?
MTNKSSLKNN-OH + H2O	sequence corresponds to the N-terminus of the yeast VHS3 protein	Homo sapiens	L-methionine + TNKSSLKNN-OH	-	?

Synonyms

Synonyms	Comment	Organism
MetAP2	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	N-terminally acetylated terminal Met residues followed by a small residue cannot be removed by MetAPs. Yeast Naa50-mediated N-terminal acetylation may act to retain the N-terminal Met residue of proteins otherwise susceptible to MetAP	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)