Literature summary for 3.4.11.18 extracted from

Vanunu, M.; Schall, P.; Reingewertz, T.H.; Chakraborti, P.K.; Grimm, B.; Barkan, D.
MapB protein is the essential methionine aminopeptidase in Mycobacterium tuberculosis (2019), Cells, 8, 393 .

Search for more literature for 3.4.11.18

Protein Variants

Protein Variants	Comment	Organism
B255L	no substantial growth defect in comparison to the growth of control strains	Mycobacterium tuberculosis variant bovis
V18G	no substantial growth defect in comparison to the growth of control strains	Mycobacterium tuberculosis variant bovis
V18G/W55L	mutant has traces of enzymatic activity, and has no substantial growth defect in comparison to the growth of control strains. When isof0orm MapA is present, the 8% activity of MapB mutant V18G/W255L is sufficient for viability and normal growth, whereas bacteria without MapA can retrieve no viable colonies	Mycobacterium tuberculosis variant bovis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis variant bovis	A0A0H3M2X0	isoform MapA	-
Mycobacterium tuberculosis variant bovis	A0A0H3M9T2	isoform MapB	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Met-7-amido-4-methylcoumarin + H2O	-	Mycobacterium tuberculosis variant bovis	Met + 7-amino-4-methylcoumarin	-	?

Synonyms

Synonyms	Comment	Organism
MapB	-	Mycobacterium tuberculosis variant bovis

General Information

General Information	Comment	Organism
physiological function	isoform mapA is dispensable for growth of bacteria. Double-deletion mutants of isoforms MapA and MapB as well as the introduction of point mutations into mapB show partial, but not full, redundancy between MapB and MapA	Mycobacterium tuberculosis variant bovis
physiological function	isoform mapB is indispensable for growth of bacteria. Double-deletion mutants of isoforms MapA and MapB as well as the introduction of point mutations into mapB show partial, but not full, redundancy between MapB and MapA	Mycobacterium tuberculosis variant bovis

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Release 2023.1 (January 2023)